Chinese self-report version of biological rhythms interview for assessment in neuropsychiatry (C-BRIAN-SR) - psychometric properties and prospective follow-up in patients with non-seasonal depression

Figures & data

Table 1. Clinical characteristics of study participants.

	MDE Group N = 80	HC Group N = 80	P value
Age (years)	41.9 ± 15.5	39.9 ± 15.3	.42
Female (N, %)	60, 74	44, 55	0.013
	MDE Group	HC Group	P value^a	B (95% CI)
HADS
Total score	24.4 ± 8.6	10.9 ± 6.1	<0.001	13.3 (10.9–15.8)
Subscale: Anxiety	12.4 ± 4.4	5.6 ± 3.5	<.001	6.7 (5.4–9.0)
Subscale: Depression	12.1 ± 4.9	5.3 ± 3.4	<.001	6.7 (5.3–8.1)
ISI	17.9 ± 6.5	7.7 ± 4.5	<.001	9.8 (8.0–11.6)
MEQ	49.2 ± 10.65	51.6 ± 8.86	.16	−2.3 (−5.5–0.88)
Eveningness (N, %)	20, 24	10, 12.5	.13
C-BRIAN-SR
Total score	47.3 ± 10.3	31.7 ± 7.9	<.001	14.9 (11.9–17.9)
Subscale: Sleep	13.9 ± 3.36	9.4 ± 2.70	<.001	4.4 (3.4–5.3)
Subscale: Activity	13.4 ± 3.76	8.3 ± 2.55	<.001	5.0 (4.0–6.0)
Subscale: Social Rhythms	10.5 ± 2.92	6.9 ± 2.52	<.001	3.5 (2.7–4.4)
Subscale: Dietary Habits	9.5 ± 3.46	6.9 ± 2.27	<.001	2.5 (1.6–3.5)

Values are presented as means ± standard deviations.

^aAll linear logistic regression analyses adjusted for gender.

C-BRIAN-SR: Chinese self-reporting version of the Biological Rhythms Interview of Assessment in Neuropsychiatry, MEQ: Morningness-Eveningness Questionnaire, ISI: Insomnia Severity Index, HADS: Hospital Anxiety and Depression Scale.

Table 2. Exploratory factor analysis of the C-BRIAN-SR.

	Factor
C-BRIAN-SR	Sleep/Social Rhythm	Sleep/Chronotype	Social Rhythm	Diet
Q1	0.79
Q5	0.76
Q7	0.73
Q6	0.65
Q9	0.64
Q2	0.58
Q3	0.53
Q21		0.71
Q19		0.70
Q20		0.67
Q4		0.47
Q12			0.72
Q13			0.70
Q10			0.65
Q14			0.61
Q11			0.59
Q8			0.53
Q17				0.76
Q16				0.73
Q15				0.67
Q18				0.43

Table 3. Correlation between C-BRIAN-SR to clinical outcomes.

			MEQ score	ISI score	HADS Anxiety score	HADS Depression score
Baseline
MDE Group	C-BRIAN-SR	Pearson Correlation	−.299**	.559**	.594**	.540**
		Sig. (2-tailed)	.009	<.001	<.001	<.001
		N	75	75	74	73
HC Group	C-BRIAN-SR	Pearson Correlation	−.158	.514**	.339*	.265*
		Sig. (2-tailed)	.165	<.001	.003	.023
		N	79	79	74	74
Follow-up
MDE Group	C-BRIAN-SR	Pearson Correlation	−.291*	.632**	.558**	.435**
		Sig. (2-tailed)	.019	<.001	<.001	<.001
		N	65	62	66	64
HC Group	C-BRIAN-SR	Pearson Correlation	.051	.535**	.376*	.338*
		Sig. (2-tailed)	.757	<.001	.020	.036
		N	39	38	38	39

*Correlation is significant at the 0.05 level (2-tailed).

**Correlation is significant at the 0.01 level (2-tailed).

Table 4. Reliability analysis of the C-BRIAN-SR.

Item	Scale Mean if Item Deleted	Corrected Item-Total Correlation	Cronbach’s Alpha if Item Deleted
1	36.98	0.647	0.915
2	37.13	0.588	0.917
3	37.15	0.582	0.917
4	36.94	0.369	0.922
5	36.92	0.604	0.916
6	36.99	0.676	0.915
7	37.19	0.699	0.914
8	37.15	0.647	0.915
9	37.16	0.740	0.913
10	37.46	0.523	0.919
11	37.06	0.738	0.913
12	37.32	0.475	0.920
13	37.14	0.704	0.914
14	37.20	0.682	0.914
15	37.23	0.653	0.915
16	37.26	0.538	0.918
17	37.21	0.629	0.916
18	37.54	0.304	0.923
Total			0.921

Figure 1. Receiver operating characteristic (ROC) curve of the cut-off point of the C-BRIAN-SR in differentiating patients with MDE from controls.

Data availability statement

Data is available upon reasonable request made to the corresponding author.