Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes

Figures & data

Figure 1. Linkage disequilibrium structure in 9p21. This Haploview image shows three distinct haploblocks formed by 23 SNPs genotyped in the original Finnish case-control cohort. The replicated SNPs (boxed) are all located in Haploblock 1, which spans the region of three genes that associate with coronary artery disease and type 2 diabetes.

Table 1. The results of four associating SNPs from the original Finnish case-control cohort as well as from the replication case-control cohorts in Finland and UK and from the family replication cohorts in Finland and Australia/New Zealand.

			Finnish case-controls										Finnish families
			Original case-control dataset 281 cases, 349 controls					Combined case-control datasets (original and FINNPEC) 669 cases, 690 controls
Marker	Location^a	Alternative allele	Freq in cases	Freq in controls	χ^2	p val (adjusted^b)	OR (95% CI)	Freq in cases	Freq in controls	χ^2	p val	OR (95% CI)	Freq	PDTPHASE p val
rs7044859	22018782	A	0.52	0.45	7.3	0.007 (0.100)	1.36 (1.09–1.71)	0.49	0.47	0.6	0.435	1.06 (0.91–1.24)	0.55	0.048
rs496892	22024352	T	0.45	0.51	5.1	0.024 (0.289)	0.77 (0.62–0.97)	NA	NA	NA	NA	NA	0.44	0.277
rs564398	22029548	C	0.38	0.45	6.7	0.010 (0.137)	0.74 (0.59–0.93)	NA	NA	NA	NA	NA	0.30	0.062
rs7865618	22031006	G	0.38	0.46	8.1	0.004 (0.07)	0.72 (0.57–0.90)	0.40	0.44	3.1	0.080	0.87 (0.75–1.02)	0.31	0.062
			UK case-controls 237 cases, 199 controls					Australian/New Zealand families
Marker	Location^a	Alternative allele	Freq in cases	Freq in controls	χ^2	p val	OR (95% CI)	Freq	PDTPHASE p val
rs7044859^c	22018782	A	NA	NA	NA	NA	NA	0.45	0.921
rs496892	22024352	T	0.47	0.47	0.005	0.945	0.99 (0.76–1.30)	0.49	0.560
rs564398	22029548	C	0.39	0.43	1.1	0.298	0.87 (0.66–1.14)	NA	NA
rs7865618	22031006	G	0.43	0.44	0.02	0.888	0.98 (0.75–1.28)	NA	NA

While not all four SNPs were genotyped in all cohorts, all SNPs were genotyped in at least some of the replication cohorts.

a Location in bp in Chr9 (genome assembly GRCh38.p2).

b Max(T) permutation corrected p value (10,000 permutations).

c Not in the Hardy–Weinberg equilibrium in controls in the UK case-control dataset.