Effect of age, period and birth–cohort on the frequency of glucose-6-phosphate dehydrogenase deficiency in Sardinian adults

Figures & data

Table 1. Frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency by age decade and gender in 11,252 Sardinian patients undergoing endoscopic procedures.

	Males		Females			Total
Age decade	Total M	G6PD deficiency M^a	Total F	G6PD total deficiency F^a	G6PD partial deficiency F^a	Total M + F	G6PD deficiency M + F
<30	375	32 (8.5%)	896	16 (1.8%)	112 (12.5%)	1271	160 (12.6%)
30–39	560	44 (7.9%)	888	23 (2.6%)	98 (11.0%)	1448	165 (11.4%)
40–49	634	52 (8.2%)	1098	21 (1.9%)	119 (10.8%)	1732	192 (11.1%)
50–59	695	53 (7.6%)	1212	35 (2.9%)	145 (11.9%)	1907	233 (12.2%)
60–69	892	69 (7.7%)	1294	30 (2.3%)	152 (11.7%)	2186	251 (11.5%)
70–79	662	54 (8.2%)	941	16 (1.7%)	109 (11.6%)	1603	179 (11.2%)
80–89	415	33 (8.0%)	555	3 (0.5%)	58 (10.4%)	970	94 (9.7%)
≥90	44	3 (6.8%)	91	1 (1.1%)	10 (11.1%)	135	14 (10.4%)
Total	4277	340 (7.9%)	6975	145 (2.1%)	803 (11.5%)	11252	1288 (11.4%)

^a Mantel–Haenszel test of trend: males 0.066; p = .797. Females with total deficiency 0.005; p = .946; females with partial deficiency 0.031; p = .860.

Table 2. Frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency according to birth cohort and gender in 11,252 Sardinian patients undergoing endoscopic procedures.

	Men		Women			Total
Birthcohort	Total M	G6PD deficiency M^a	Total F	G6PD total deficiency F^a	G6PD partial deficiency^a	Total M + F	G6PD deficiency M + F
<1930	491	45 (9.2%)	684	7 (1.0%)	77 (11.3%)	1175	129 (11.0%)
1930–39	776	65 (8.4%)	1095	12 (1.1%)	120 (11.0%)	1871	197 (10.5%)
1940–49	833	55 (6.6%)	1290	33 (2.6%)	157 (12.2%)	2123	245 (11.5%)
1950–59	699	58 (8.3%)	1175	30 (2.6%)	144 (12.3%)	1874	232 (12.4%)
1960–69	677	50 (7.4%)	1133	29 (2.6%)	108 (9.5%)	1810	187 (10.3%)
1970–79	521	47 (9.0%)	913	20 (2.2%)	110 (12.0%)	1434	177 (12.3%)
≥1980	280	20 (7.1%)	685	14 (2.0%)	87 (12.7%)	965	121 (12.5%)
Total	4277	340 (7.9%)	6975	145 (2.1%)	803 (11.5%)	11252	1288 (11.4%)

^a Mantel–Haenszel test of trend: males 0.167; p = .682. Females with total deficiency 1.195; p = .274; females with partial deficiency 3.160; p = .075.

Figure 1. Variation of G6PD deficiency estimated by Poisson log-linear regression according to age, birth cohort and time period (calendar time) in 11,252 Sardinian patients stratified by gender. The categories chosen for reference are as follows: by age (left) ≥ 90 years; by birth cohort (middle) the generations born after 1980; by time period (right) the interval 2000–2016.