A 30-year follow-up study of patients with Melkersson–Rosenthal syndrome shows an association to inflammatory bowel disease

Figures & data

Table 1. Patient characteristics.

No. of patients	27
Female	17 (63%)
Male	10 (37%)
Median age in years (range)
At initial presentation of symptoms	24 (10–71)
At diagnosis	38 (23–73)
At study appointment	57.8 (41.4–87.0)
Median duration in years (range)
Follow-up after diagnosis	15.4 (10.9–34.9)
Follow-up after presentation of symptoms	29.7 (11.4–63.7)
Diagnoses
Melkersson–Rosenthal syndrome (triad or oligosymptomatic form)	13 (48.1%)
Cheilitis granulomatosa	14 (51.9%)

Table 2. Reported symptoms in patients with MRS t/o or CG within the course of the disease (ever) and within the last year before the study interview (last year).

	All		MRS t/o		CG
	27		13		14
No. of patients	Ever	Last year	Ever	Last year	Ever	Last year
Labial oedema	17 (63.0%)	5 (18.5%)	7 (53.8%)	2 (15.4%)	10 (71.4%)	3 (21.4%)
Recurrent	10	2	6	1	4	1
Nonrecurring	5	1	0	0	5	1
Persistent	2	2	1	1	1	1
Both lips	7	2	2	1	5	1
Upper lip	5	1	3	1	2	0
Lower lip	5	2	2	0	3	2
Bilateral	12	4	4	1	8	3
Unilateral	5	1	3	1	2	0
Facial oedema	9 (33.3%)	6 (22.2%)	4 (30.8%)	3 (23.1%)	5 (35.7%)	3 (21.4%)
Recurrent	8	6	4	3	4	3
Nonrecurring	1	0	0	0	1	0
Bilateral	4	3	0	0	4	3
Unilateral	5	3	4	2	1	1
Location of facial oedema
Nose and close to nose	2	2	1	1	1	1
Jaw	2	0	1	0	1	0
Around the mouth	3	2	0	0	3	2
Neck, cheek, under the eyes	1	1	1	1	0	0
Oedema in other parts of the body	6 (22.2%)	0	2 (15.4%)	0	4 (28.6%)	0
Facial palsy	13 (48.1%)	1 (3.7%)	13 (100%)	1 (7.7%)	0	0
Recurrent	9	1	9	1	0	0
Nonrecurrent	4	0	4	0	0	0
Fissured tongue	11 (40.7%)		9 (69.2%)		2 (14.3%)

MRS t/o: triad or oligosymtomatic Melkersson–Rosenthal syndrome; CG: cheilitis granulomatosa.