Figures & data
Table 1. Characteristics of included studies in this meta-analysis.
Figure 2. Forest plot of included studies assessing the sensitivity and specificity of circulating miR-21 in CRC.
![Figure 2. Forest plot of included studies assessing the sensitivity and specificity of circulating miR-21 in CRC.](/cms/asset/c2be40e3-c8dd-4bf3-918c-99abef432474/iann_a_1828617_f0002_c.jpg)
Figure 9. Forest plot of included Chinese studies assessing the sensitivity and specificity of circulating miR-21 in CRC.
![Figure 9. Forest plot of included Chinese studies assessing the sensitivity and specificity of circulating miR-21 in CRC.](/cms/asset/519bf5db-c1dd-4e5a-8654-323fc2312b10/iann_a_1828617_f0009_c.jpg)
Figure 12. Forest plot of included studies using SYBR-Green qRT-PCR as test method assessing the sensitivity and specificity of circulating miR-21 in CRC.
![Figure 12. Forest plot of included studies using SYBR-Green qRT-PCR as test method assessing the sensitivity and specificity of circulating miR-21 in CRC.](/cms/asset/e15b5aa3-d930-432d-848d-0382ff3ae042/iann_a_1828617_f0012_c.jpg)
Figure 13. Forest plot of included studies using SYBR-Green qRT-PCR as test method assessing the PLR of circulating miR-21 in CRC.
![Figure 13. Forest plot of included studies using SYBR-Green qRT-PCR as test method assessing the PLR of circulating miR-21 in CRC.](/cms/asset/12700b46-b3aa-4c94-8a7a-f795ccea9c04/iann_a_1828617_f0013_c.jpg)
Figure 14. Forest plot of included studies using SYBR-Green qRT-PCR as test method assessing the NLR of circulating miR-21 in CRC.
![Figure 14. Forest plot of included studies using SYBR-Green qRT-PCR as test method assessing the NLR of circulating miR-21 in CRC.](/cms/asset/ef99fb1d-0b62-457e-9d75-dd42f0fa5365/iann_a_1828617_f0014_c.jpg)
Figure 15. Forest plot of included studies using TaqMan qRT-PCR as test method assessing the sensitivity and specificity of circulating miR-21 in CRC.
![Figure 15. Forest plot of included studies using TaqMan qRT-PCR as test method assessing the sensitivity and specificity of circulating miR-21 in CRC.](/cms/asset/2af74128-f6db-4030-b5c4-e5da942b07db/iann_a_1828617_f0015_c.jpg)
Figure 16. Forest plot of included studies using TaqMan qRT-PCR as test method assessing the PLR of circulating miR-21 in CRC.
![Figure 16. Forest plot of included studies using TaqMan qRT-PCR as test method assessing the PLR of circulating miR-21 in CRC.](/cms/asset/93794463-6c17-4aba-856b-33dbc9461ec5/iann_a_1828617_f0016_c.jpg)
Figure 17. Forest plot of included studies using TaqMan qRT-PCR as test method assessing the NLR of circulating miR-21 in CRC.
![Figure 17. Forest plot of included studies using TaqMan qRT-PCR as test method assessing the NLR of circulating miR-21 in CRC.](/cms/asset/7eb54108-7f61-4ef1-8e72-4b40e0e39950/iann_a_1828617_f0017_c.jpg)
Figure 18. Forest plot of included studies using U6 snRNA as internal reference gene assessing the sensitivity and specificity of circulating miR-21 in CRC.
![Figure 18. Forest plot of included studies using U6 snRNA as internal reference gene assessing the sensitivity and specificity of circulating miR-21 in CRC.](/cms/asset/7591df56-733f-4d5f-8db1-b81ba48e31bd/iann_a_1828617_f0018_c.jpg)
Figure 19. Forest plot of included studies using U6 snRNA as internal reference gene assessing the PLR of circulating miR-21 in CRC.
![Figure 19. Forest plot of included studies using U6 snRNA as internal reference gene assessing the PLR of circulating miR-21 in CRC.](/cms/asset/c03f988f-6c32-4a5d-9c93-288925593c93/iann_a_1828617_f0019_c.jpg)
Figure 20. Forest plot of included studies using U6 snRNA as internal reference gene assessing the NLR of circulating miR-21 in CRC.
![Figure 20. Forest plot of included studies using U6 snRNA as internal reference gene assessing the NLR of circulating miR-21 in CRC.](/cms/asset/29a6f86c-47c4-42b5-97c0-cc530a8a41c9/iann_a_1828617_f0020_c.jpg)
Figure 21. Forest plot of included studies using miR-16 as internal reference gene assessing the sensitivity and specificity of circulating miR-21 in CRC.
![Figure 21. Forest plot of included studies using miR-16 as internal reference gene assessing the sensitivity and specificity of circulating miR-21 in CRC.](/cms/asset/df900689-d1da-4c94-8424-3f6e9a1161d4/iann_a_1828617_f0021_c.jpg)
Figure 22. Forest plot of included studies using miR-16 as internal reference gene assessing the PLR of circulating miR-21 in CRC.
![Figure 22. Forest plot of included studies using miR-16 as internal reference gene assessing the PLR of circulating miR-21 in CRC.](/cms/asset/aeb10ea1-45f9-4433-9cf2-629f8b2e3a11/iann_a_1828617_f0022_c.jpg)
Figure 23. Forest plot of included studies using miR-16 as internal reference gene assessing the NLR of circulating miR-21 in CRC.
![Figure 23. Forest plot of included studies using miR-16 as internal reference gene assessing the NLR of circulating miR-21 in CRC.](/cms/asset/e33f2e40-8d0f-4989-951c-4da5531e6039/iann_a_1828617_f0023_c.jpg)
Table 2. Possible sources of heterogeneity of covariants in the meta-regression analysis.