Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis

Figures & data

Table 1. Analysis of clinical value in the ruptured OE group and control group.

	Ruptured OE	Unruptured OE	p Value
Numbers of patients	21	152
Age(y) (mean ± SD)	33.0 ± 7.3	32.2 ± 6.9	NS
CA-125 (U/ml) (mean ± SD)	852.50 ± 1002.70	70.53 ± 64.49	.0001
D-dimer (mg/L) (mean ± SD)	3.40 ± 4.90	0.43 ± 0.29	.0001
FIB (g/L) (mean ± SD)	6.41 ± 6.44	2.55 ± 0.58	.0001
CA19-9 (U/ml) (mean ± SD)	343.09 ± 367.67	36.84 ± 40.01	.0001
Diameter (cm) (mean ± SD)	7.51 ± 3.33	7.07 ± 2.09	.160

Table 2. Level of CA-125, CA19-9 and D-dimer in the ruptured OE group.

	CA-125 (U/ml)	CA19-9 (U/ml)	D-dimer (mg/L)
	(mean ± SD)	(mean ± SD)	(mean ± SD)
Side of occurrence
Unilateral	884.92 ± 1039.83	369.18 ± 386.25	3.56 ± 5.24
Bilateral	658.00 ± 892.96	186.52 ± 202.10	2.40 ± 2.19
p Value	0.796	0.503	0.510
Stage
Minimal to mild(I-II)	960.08 ± 907.93	427.65 ± 519.98	1.98 ± 2.18
Moderate to severe  (III-IV)	786.31 ± 1087.37	291.05 ± 244.72	4.27 ± 5.92
p Value	0.962	0.271	0.242

Table 3. Level of CA-125 and CA19-9 in the unruptured OE group.

	CA-125 (U/ml)	CA19-9 (U/ml)
	(mean ± SD)	(mean ± SD)
Side of occurrence
Unilateral	58.91 ± 59.99	30.69 ± 29.60
Bilateral	89.89 ± 67.56	47.09 ± 51.72
p Value	0.095	0.036
Stage
Minimal to mild(I-П)	55.59 ± 30.71	27.13 ± 29.16
Moderate to severe (III-IV)	80.00 ± 77.45	43.00 ± 44.64
p Value	0.004	0.093

Figure 1. ROC curve for CA-125, CA199, D-dimer and the combined markers for differentiating patients withspontaneously ruptured OE. (A) The AUC value of CA-125, CA199 combined with D-dimer wasthe highest compared with the other groups. (B) The AUC value of OE diameter.

Table 4. Performance of serum concentration of CA-125, CA19-9 and D-dimer in distinguishing the ruptured ovarian endometriosis.

	AUC	AUC (95% CI)	Youden index J	Cut off value	Sensitivity (%)	Specificity (%)	+LR	−LR	p Value
CA-125	0.912	0.859 − 0.950	0.7124	108.1	85.71	85.53	5.92	0.17	<.0001
CA19-9	0.918	0.867–0.955	0.7503	95.1	80.95	94.08	13.67	0.2	<.0001
D-dimer	0.924	0.874–0.959	0.6717	0.6	85.71	81.46	4.62	0.18	<.0001
CA-125 + CA19-9	0.945	0.899–0.974	0.7798	–	90.48	87.50	7.24	0.11	<.0001
CA-125 + D-dimer	0.964	0.924 − 0.986	0.7789	–	90.48	87.42	7.19	0.11	<.0001
CA19-9 + D-dimer	0.975	0.939 − 0.993	0.8240	–	85.71	96.69	25.89	0.15	<.0001
CA-125 + CA19-9 + D-dimer	0.976	0.940–0.993	0.8274	-	95.24	87.50	7.62	0.05	<.0001
Diameter	0.514	0.436 − 0.591	0.1200	5.7	66.67	21.33	–	–	.8510

Data availability statement

Data generated or analysed during this study are included in this published article. The datasets generated during and/or analysed during this study are available from the corresponding author on reasonable request.