Estimated glomerular filtration rate partially recovered in patients without Hypertriglyceridemia during Tenofovir disoproxil fumarate treatment

Figures & data

Table 1. Demographic and clinical characteristics of the patients.

Variables	TG ≥1.7 mmol/L (n = 20)	TG <1.7 mmol/L (n = 183)	Z or χ2 Value	p value
Age	36.0 (32.0–50.8)	36.0 (32.0–46.0)	0.365	0.72
Male, n (%)	18 (90.0)	132 (72.1)	1.723	0.10
Creatinine, μmol/L	73.1 (65.3–82.5)	70.0 (59.0–81.0)	1.077	0.28
LC, n (%)	3 (15.0)	32 (17.5)	0.279	0.78
eGFR,ml/(min·1.73m^2)	106.3 (102.8–122.6)	112.5 (97.0–135.0)	0.645	0.52
eGFR categories,
<90, n (%)	2 (10.0)	29 (15.9)	0.476	0.75
≥90, n (%)	18 (90.0)	154 (84.1)
ALT, U/L	184.0 (40.2–555.0)	56.0 (31.7–144.0)	1.956	0.05
HBV DNA, Log10IU/mL	4.6 (3.2–6.6)	5.2 (3.3–7.0)	0.107	0.92
Cholesterol, mmol/L	4.4 (3.2–5.0)	3.8 (3.3–4.4)	1.894	0.06
TG, mmol/L	2.2 (1.9–2.6)	0.9 (0.6–1.1)	7.337	<0.01
ALT normalization rate at the 3rd year, n (%)	16 (80.0)	151 (82.5)	0.279	0.78
Undetectable HBV DNA at the 3rd year, n (%)	19 (95.0)	175 (95.6)	0.129	0.90

Comparison was performed using Mann-Whitney U test or chi-square test. LC: liver cirrhosis; eGFR: estimated glomerular filtration rate; TG: triglyceride; ALT: alanine aminotransferase.

Table 2. Risk factors for partial recovery of eGFR in patients with TG <1.7 mmol/L.

	Univariate			Multivariate
Baseline variables	Odds ratio	95% CI	p	Odds ratio	95% CI	p
Age	0.874	0.795–0.960	<0.01	0.886	0.817–0.960	<0.01
Sex	1.122	0.266–4.727	0.88
LC	0.343	0.047–2.517	0.29
ALT	1.002	0.999–1.006	0.22
AST	0.999	0.994–1.004	0.76
TG	1.360	0.621–2.976	0.44
Cholesterol	0.712	0.339–1.493	0.37
eGFR <90 ml/(min·1.73m^2)	0.089	0.021–0.378	<0.01	0.073	0.019–0.284	<0.01

LC: liver cirrhosis; eGFR: estimated glomerular filtration rate; TG: triglyceride; ALT: alanine aminotransferase; AST: aspartate aminotransferase.

Figure 1. Dynamic changes of eGFR, TG, and CHOL in patients with and without hypertriglyceridemia. (A) total population; (B) patients with hypertriglyceridemia; (C) patients without hypertriglyceridemia. *, p < 0.05. eGFR, estimated glomerular filtration rate; TG, triglyceride; CHOL, cholesterol.

Figure 2. Comparison of eGFR, TG and CHOL between patients with and without hypertriglyceridemia at different timepoints. eGFR, estimated glomerular filtration rate; TG, triglyceride; CHOL, cholesterol.

Figure 3. The correlation between eGFR and TG in patients with TG <1.7 mmol/L. eGFR, estimated glomerular filtration rate; TG, triglyceride; CHOL, cholesterol.

Data availability statement

The data are available from the corresponding author upon request.