Can circadian rhythm predict changes in neurocognitive functioning in bipolar disorder: protocol of a 12-month longitudinal cohort study based on research domain criteria

Figures & data

Figure 1. Flow diagram illustrating the procedures for participant enrollment and assessment.

Table 1. Schedule of enrolment and assessment.

Time point		Study periods
		Baseline	6-month follow-up	12-month follow-up
Enrolment	Eligibility screen, informed consent, assessments	×
Clinical assessment	HAMD-17, HAMA-14, YMRS, CGI-BP, SAS, SDS	×	×	×
Circadian rhythm assessment	MEQ, SPAQ	×
	Actigraphy, PSQI	×	×	×
Neurocognitive assessment	DMS, PAL, RVP and SWM tests in CANTAB	×	×	×

Note: SAS: Zung’s self-rating anxiety scale; SDS: Zung’s self-rating depression scale; HAMD-17 : 17-item hamilton depression scale; HAMA-14:14-item hamilton anxiety scale; YMRS: young mania rating scale; CGI-BP: clinical global impressions-bipolar version; MEQ: morningness eveningness questionnaire; SPAQ: seasonal pattern assessment questionnaire; PSQI: Pittsburgh sleep quality index; DMS: delayed matching to sample; PAL: paired associates learning; RVP: rapid visual information processing; SWM: spatial working memory; CANTAB: Cambridge neuropsychological test automated battery.

Data availability statement

Not applicable.