Combined proteomics and transcriptomics identifies serpin family C member 1 associated protein as a biomarker of endometriosis

Figures & data

Table 1. Characteristics of females participating in the research and variables assessed during the menstrual cycle.

Index	Group control LH + 7 (n = 7)	Group EMT LH + 7 (n = 7)
Age (years)	34.28 ± 3.49	33.57 ± 2.43
BMI	22.52 ± 1.03	21.55 ± 0.71
Plasma estradiol^a (pg/ml)	166.10 ± 89.75	204.57 ± 62.25
Plasma progesterone^a (ng/ml)	11.01 ± 3.71	13.08 ± 5.54

^aOn the day of biopsy.

Figure 1. The Gene Ontology (GO) terms, KEGG pathway analyses, scatter plots and volcano indicate the difference of mRNA expression between the two clusters. (A) The volcano and scatter plots. (B) The GO molecular function research identified 30 enriched GO terms. (C)(D) The WikiPathway, Reactome and KEGG pathway analyses.

Figure 2. The GO terms, KEGG pathway analyses, PPI, scatter plots and volcano show the difference of protein expression between the two groups. (A) The volcano and scatter plots. (B) The GO molecular function. (C) The PPI network. (D) The KEGG enrichment analysis.

Figure 3. Venn analysis was used to integrate the RNA-seq and protein profiles.

Table 2. Characteristics of women participating in the ELISA evaluating study.

Index	Group control (n = 22)	Group EM (n = 22)	p Value
Age (years)	29.81 ± 5.72	32.63 ± 5.35	0.099
BMI	21.82 ± 3.99	22.34 ± 3.32	0.638
SERPINC1 (ng/ml)	98511.82 ± 22710.70	82792.72 ± 17457.20	0.014
FETUB (ng/ml)	2744.76 ± 390.11	2867.28 ± 379.23	0.308

Availability of data and materials

The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.