Figures & data
Figure 1. Potential BAI, BAE, and WOG action mechanisms in HCC treatment. BAE, BAI, and WOG affected cell apoptosis by inhibiting the expression of Bcl-2/Bax and migration by activating the ER stress and ROS pathway. BAE starts the effect of cell-cycle regulation by inhibiting the expression and function of cell-cycle genes, including CyclinE, CyclinD1, CyclinB1, CyclinA2, and CDK. BAE, BAI, and WOG induce autophagy, cell cycle, and necrosis by PI3K/Akt/mTOR, Hippo, and Nf-KB pathways. BAI and BAE inhibited migration by decreasing adhesion molecule release. Abbreviation: BAI, baicalin, BAE, baicalein, WOG, Wogonin.
![Figure 1. Potential BAI, BAE, and WOG action mechanisms in HCC treatment. BAE, BAI, and WOG affected cell apoptosis by inhibiting the expression of Bcl-2/Bax and migration by activating the ER stress and ROS pathway. BAE starts the effect of cell-cycle regulation by inhibiting the expression and function of cell-cycle genes, including CyclinE, CyclinD1, CyclinB1, CyclinA2, and CDK. BAE, BAI, and WOG induce autophagy, cell cycle, and necrosis by PI3K/Akt/mTOR, Hippo, and Nf-KB pathways. BAI and BAE inhibited migration by decreasing adhesion molecule release. Abbreviation: BAI, baicalin, BAE, baicalein, WOG, Wogonin.](/cms/asset/ddd9951c-3dcb-4f12-9929-8ccbfcf1483d/iann_a_2247004_f0001_c.jpg)
Table 1. Meta-analysis of clinical outcomes.
Table 2. Meta-analysis of preclinical outcome in vivo studies.
Table 3. Meta-analysis for Bcl-2, MMP-2, MMP-9, caspase-3, and CyclinD1 (in vitro studies).
Supplemental Material
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