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Annals of Medicine Volume 55, 2023 - Issue 2
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Public Health

Developing and validating clinical models to identify candidates for allergic rhinitis pre-exposure prophylaxis

Wenting Luoa Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaORCID Iconhttps://orcid.org/0000-0001-9356-7126View further author information
ORCID Icon,
Xiangqing Houb Guangzhou National Laboratory, Guangzhou, ChinaORCID Iconhttps://orcid.org/0000-0002-9475-8482View further author information
ORCID Icon,
Yun Sunc Department of Pediatrics, Yinchuan Maternal and Child Health Care Hospital, Yinchuan, ChinaORCID Iconhttps://orcid.org/0000-0003-2721-9259View further author information
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Hong Zhangd Department of Pediatrics, Gansu Provincial Hospital, Lanzhou, ChinaORCID Iconhttps://orcid.org/0000-0002-6067-1477View further author information
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Huali Rene Department of Allergy, State Grid Beijing Electric Power Hospital, Capital Medical University Electric Power Teaching Hospital, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0002-8447-4793View further author information
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Xiangping Maf Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Wulumuqi, ChinaORCID Iconhttps://orcid.org/0000-0003-1467-6709View further author information
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Guoping Lig Laboratory of Allergy and Precision Medicine, Chengdu Institute of Respiratory Health, the Third People’s Hospital of Chengdu, Chengdu, ChinaORCID Iconhttps://orcid.org/0000-0003-3360-6124View further author information
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Yongmei Yuh Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaORCID Iconhttps://orcid.org/0000-0002-7223-8793View further author information
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Jianxin Suni Department of Respiratory, The Second People’s Hospital of Zhaoqing, Zhaoqing, ChinaORCID Iconhttps://orcid.org/0000-0001-7956-5925View further author information
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Huajie Wuj Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaORCID Iconhttps://orcid.org/0000-0003-4344-5125View further author information
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Jing Wuk Department of Allergy and Clinical Immunology, Inner Mongolia Cancer Hospital, Inner Mongolia, ChinaORCID Iconhttps://orcid.org/0000-0002-4543-0915View further author information
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Ruifen Zhongl Department of Clinical Lab, Dongguan Eighth People’s Hospital, Dongguan, ChinaORCID Iconhttps://orcid.org/0000-0001-8376-5487View further author information
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Siqin Wangm Department of Allergy and Clinical Immunology, Henan Provincial People’s Hospital, Zhengzhou, ChinaORCID Iconhttps://orcid.org/0000-0003-3601-7827View further author information
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Zhenan Lin Department of Otolaryngology, Foshan Maternal Child Health Hospital, Foshan, ChinaORCID Iconhttps://orcid.org/0000-0002-7785-0789View further author information
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Yan Zhaoo Department of Allergy, The First Affiliated Hospital of Harbin Medical University, Harbin, ChinaORCID Iconhttps://orcid.org/0000-0002-2700-3514View further author information
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Liting Wup Department of Clinical Laboratory, Shenzhen Pingle Orthopedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, ChinaORCID Iconhttps://orcid.org/0000-0003-2442-3924View further author information
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Xianhui Zhenga Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, ChinaORCID Iconhttps://orcid.org/0000-0002-0385-7523View further author information
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Miaoyuan Xuq KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Qingyuan Yeq KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Chuangli Haor Department of Respirology, Children’s Hospital, Soochow University, Suzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8203-0603View further author information
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Baoqing Suna Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China;b Guangzhou National Laboratory, Guangzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1671-0723View further author information
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Article: 2287188 | Received 12 Oct 2023, Accepted 17 Nov 2023, Published online: 01 Dec 2023

Figures & data

Table 1. Baseline demographics and clinical characteristics of patients in the training, internal, and external validation datasets.

Table 2. Demographics and questionnaire among patients in the development datasets who were allergic to at least one allergen.

Figure 1. Nomogram to predict the risk of allergic rhinitis. (A) Outcome 1 was defined as patients with allergic rhinitis (AR) who had a positive response to at least one indoor or outdoor allergen; (B) outcome 2 was defined as patients with AR who had a positive response to at least one outdoor pollen allergen.

Figure 1. Nomogram to predict the risk of allergic rhinitis. (A) Outcome 1 was defined as patients with allergic rhinitis (AR) who had a positive response to at least one indoor or outdoor allergen; (B) outcome 2 was defined as patients with AR who had a positive response to at least one outdoor pollen allergen.

Figure 2. Receiver operating characteristic curves of nomograms A and B.

Figure 2. Receiver operating characteristic curves of nomograms A and B.

Figure 3. Calibration curves of nomograms a and B. (A1 and B1) training datasets; (A2 and B2) internal validation datasets; and (A3 and B3) external training datasets.

Figure 3. Calibration curves of nomograms a and B. (A1 and B1) training datasets; (A2 and B2) internal validation datasets; and (A3 and B3) external training datasets.
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Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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