Prevalence of high-risk human papillomavirus infection and genotype distribution among Kazakhstani women with abnormal cervical cytology

Figures & data

Table 1. Age distribution, HPV and CIN prevalence.

Variables	Participants, N (%)
	N = 316
Age
Range	18–70
Mean + SD	36.4 ± 10.96
18–25	42/316 (13.3%)
26–30	84/316 (26.6%)
31–35	57/316 (18.0%)
36–40	31/316 (9.8%)
41–45	34/316 (10.8%)
46–50	20/316 (6.3%)
51–55	22/316 (7.0%)
≥56	26/316 (8.2%)
Pap-test
Negative	207/316(65.5%)
Abnormal	109/316 (34.5%)
LSIL	94/109 (86.2%)
HSIL	15/109 (13.8%)
HPV infection
HPV positive	133/316 (42.1%)
HPV negative	183/316 (57.9%)
HPV positive	N = 133
Single HPV type	100/133 (75.2%)
Multiple HPV types (n > 2)	33/133 (24.8%)
HPV genotype (single and multiple)
HPV16	50 (15.8%)
HPV18	26 (8.2%)
HPV 31	6 (1.9%)
HPV33	20 (6.3%)
HPV35	3 (1%)
HPV39	11 (3.5%)
HPV45	8 (2.5%)
HPV51	13 (4.1%)
HPV52	13 (4.1%)
HPV56	4 (1.3%)
HPV58	8 (2.5%)
HPV59	9 (2.9%)

Figure 1. Age-specific prevalence of HPV infection. Panel A – age-specific prevalence of HPV infection; panel B – age-specific prevalence of single HPV infection; panel C – age-specific prevalence of multiple HPV infections.

Table 2. Association of HR-HPV infection and abnormal cervical cytology.

Outcomes of HPV detection, N (%) p value
Cytology results	N = 109			N = 68
	HPV positive 68/109 (62.4%)	HPV negative 41/109 (37.6%)	p Value .001	Single 49/68 (72.1%)	Multiple 19/68 (27.9%)	p Value .001
LSIL	54 (79.4%)	35 (85.4%)		43 (87.8%)	5 (26.3%)
HSIL	14 (20.6%)	1 (2.4%)		6 (12.2%)	14 (73.7%)
Total	68 (100%)	41 (100%)		49 (100%)	19 (100%)

Table 3. Prevalence of HPV types stratified by the cervical cytology result.

HR-HPV genotypes	Cytology result type
	LSIL, N (%)	HSIL, N (%)	Total, N (%)	p Value
HPV16	24 (77.4%)	7 (22.6%)	31 (100%)	.04
HPV18	10 (58.8%)	7 (41.2%)	17 (100%)	.0001
HPV31	–	2 (100%)	2 (100%)	.02
HPV33	10 (100%)	–	10 (100%)	.01
HPV35	1 (100%)	–	1 (100%)	1.00
HPV39	4 (100%)	–	4 (100%)	1.00
HPV45	2 (100%)	–	2 (100%)	1.00
HPV51	5 (100%)	–	5 (100%)	.32
HPV52	2 (33.3%)	4 (66.7%)	6 (100%)	.0001
HPV56	1 (33.3%)	2 (66.7%)	3 (100%)	.09
HPV58	6 (100%)	–	6 (100%)	.08
HPV59	2 (100%)	–	2 (100%)	.08
Total	67	22	89

Data availability statement

The study questionnaires and raw data are available from the project PI via email: [email protected]