Figures & data
Figure 1. Flow chart of the study. BDNFS: serum brain-derived neurotrophic factor; BDNFP: plasma brain-derived neurotrophic factor; BDNFS/P-ratio: brain-derived neurotrophic factor serum/plasma-ratio; CG: control group; COPD: chronic obstructive pulmonary disease; IG: intervention group.
![Figure 1. Flow chart of the study. BDNFS: serum brain-derived neurotrophic factor; BDNFP: plasma brain-derived neurotrophic factor; BDNFS/P-ratio: brain-derived neurotrophic factor serum/plasma-ratio; CG: control group; COPD: chronic obstructive pulmonary disease; IG: intervention group.](/cms/asset/651ff77b-9f06-48a0-9d03-8c1517c6f89f/iann_a_2304650_f0001_c.jpg)
Table 1. Patients’ characteristics at baseline split by group (intervention group (IG), control group (CG)). Values are presented as means ± standard deviations.
Figure 2. Acute and chronic effects of intermittent hypoxic-hyperoxic exposure (IHHE, intervention group) and sham-IHHE (control group) prior to aerobic cycling on (A) brain-derived neurotrophic factor serum blood concentration (BDNFS), (B) brain-derived neurotrophic factor plasma blood concentration (BDNFP), (C) brain-derived neurotrophic factor serum/plasma-ratio (BDNFS/P-ratio), (D) interleukin-6 (IL-6), and (E) C-reactive protein (CRP). Values are presented as individual data points and medians (horizontal lines) with the 25th and 75th percentiles. * d > 0.50 vs. pre-exercise, # d > 0.50 vs. intervention group.
![Figure 2. Acute and chronic effects of intermittent hypoxic-hyperoxic exposure (IHHE, intervention group) and sham-IHHE (control group) prior to aerobic cycling on (A) brain-derived neurotrophic factor serum blood concentration (BDNFS), (B) brain-derived neurotrophic factor plasma blood concentration (BDNFP), (C) brain-derived neurotrophic factor serum/plasma-ratio (BDNFS/P-ratio), (D) interleukin-6 (IL-6), and (E) C-reactive protein (CRP). Values are presented as individual data points and medians (horizontal lines) with the 25th and 75th percentiles. * d > 0.50 vs. pre-exercise, # d > 0.50 vs. intervention group.](/cms/asset/fcd59048-ec74-48de-9543-0575e8e5e1af/iann_a_2304650_f0002_b.jpg)
Table 2. Acute and chronic effects of intermittent hypoxic-hyperoxic exposure (IHHE, intervention group (IG)) and sham-IHHE (control group (CG)) prior to aerobic cycling on brain-derived neurotrophic factor serum blood concentration (BDNFS), brain-derived neurotrophic factor plasma blood concentration (BDNFP), brain-derived neurotrophic factor serum/plasma-ratio (BDNFS/P-ratio), interleukin-6 (IL-6), and C-reactive protein (CRP). Values are presented as means ± standard deviations.
Supplemental Material
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The raw data supporting the conclusions of this article will be made available by the authors on reasonable request.