Views

CrossRef citations to date

Altmetric

Medical Genetics & Genomics

T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea

Xinyi Lia Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Chenyang Lia Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Wenjun Xueb Department of Otorhinolaryngology Head and Neck surgery, Shanghai Eighth People’s Hospital Affiliated to Jiangsu University, Shanghai, ChinaView further author information

Zhicheng Weia Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Hangdong Shena Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Kejia Wua Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Huaming Zhua Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Huajun Xua Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaCorrespondence[email protected]
View further author information

Xiaolin Wuc Central Laboratory of Shanghai Eighth People’s Hospital, Xuhui Branch of Shanghai Sixth People’s Hospital, P. R. ChinaCorrespondence[email protected]
View further author information

Hongliang Yia Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Jian Guana Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

Shankai Yina Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, ChinaView further author information

show all

Figures & data

Table 1. Baseline characteristics of 125 matched participants with different OSA severity levels.

Download CSV Display Table

Table 2. Associations between T266M and clinical characteristics of OSA participants.

Download CSV Display Table

Figure 1. Visualization of the docked complex between human ANGPTL4 and ACACA. A: a) Interaction docking structure between wild-type ANGPTL4 and ACACA. b) Surface area visualization showing the compact fitting of ACACA. c) Surface area visualization showing the compact fitting of wild-type ANGPTL4. B: a) Interaction docking structure between mutant ANGPTL4 T266M and ACACA. b) Surface area visualization showing the compact fitting of ACACA. c) Surface area visualization showing the compact fitting of mutant ANGPTL4 T266M. C: Intra-chain interaction of wild-type ANGPTL4. D: Intra-chain interaction of mutant ANGPTL4 T266M.

Table 3. Interactions between residues located on the contact surfaces of ANGPTL4, T266M, and ACACA.

Download CSV Display Table

Figure 2. Interpretation of the stability of wild-type (WT) and mutated ANGPTL4. A: Comparison of root mean square deviation (RMSD) for WT and mutated ANGPTL4 proteins. B: Comparison of root mean square fluctuation (RMSF) for residues of WT and mutated ANGPTL4.

Figure 3. Comparison of the structures of WT and mutated ANGPTL4. A: Probability density function (PDF) map comparing WT and mutated ANGPTL4 in a) backbone hydrogen bonds; b) side chain hydrogen bonds; c) hydrogen bonds at residue 266; d) solvent-accessible surface area; e) solvent-accessible surface area of hydrophobic residues; f) solvent-accessible surface area of hydrophilic residues. B: a) Secondary structure of WT ANGPTL4 protein; b) Secondary structure of mutant (MT) ANGPTL4 protein.

Supplemental material

Supplemental Material

Download Zip (5 MB)

T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea

Table 1. Baseline characteristics of 125 matched participants with different OSA severity levels.

Table 2. Associations between T266M and clinical characteristics of OSA participants.

Table 3. Interactions between residues located on the contact surfaces of ANGPTL4, T266M, and ACACA.

Supplemental Material

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea

Figures & data

Table 1. Baseline characteristics of 125 matched participants with different OSA severity levels.

Table 2. Associations between T266M and clinical characteristics of OSA participants.

Table 3. Interactions between residues located on the contact surfaces of ANGPTL4, T266M, and ACACA.

Supplemental Material

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date