Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study

Figures & data

Table 1. Characteristics of the study population with ulcerative colitis or Crohn’s disease.

Age (y)	45.0 (11.0)
Sex (men/women)	15/59
CD/UC (%)	50/50
Disease duration (y)	10.8 (8.4)
Faecal calprotectin (μg/g)	212 (342)
Cortisol in hair (μg/mL)	1.9 (3.0)
C-reactive protein (mg/dL)	2.0 (2.7)
IBDQ-32	10.5 (4.6)
HADS Anxiety	10.6 (4.6)
HADS Depression	6.2 (4.3)

Abbreviations: CD = Crohn’s disease; UC = ulcerative colitis; IBDQ = Inflammatory Bowel Disease Questionnaire; HADS = Hospital Anxiety and Depression Scale.

Data are presented as means with SD.

Table 2. Correlation coefficients for the Inflammatory Bowel Disease Questionnaire-32 and independent variables.

Variables	FC	CRP	Cortisol in hair	HADS-A	HADS-D
IBDQ-32	0.219	−0.103	0.102	−0.651*	−0.611*
FC		0.073	0.032	−0.278	−0.108
CRP			−0.010	0.014	0.120
Cortisol in hair				−0.229	−0.194
HADS-A					0.684*

Abbreviations: CRP = C-reactive protein; FC = faecal calprotectin ; HADS = Hospital Anxiety and Depression Scale and IBDQ = Inflammatory Bowel Disease Questionnaire, *p < 0.01.

Table 3. Multiple stepwise linear regression analyses with the Inflammatory Bowel Disease Questionnaire-32 as the dependent variable.

	IBDQ-32
Independent variables	R^2	Adjusted R^2	R^2 change	Standardised Beta coefficient	Beta significance
Model 1	0.42	0.41	0.42
HADS-A				−0.65	< 0.001
Model 2	0.47	0.45	0.05
HADS-A				−0.43	0.002
HADS-D				−0.31	0.025

Abbreviations: HADS-A = Hospital Anxiety and Depression Scale-Anxiety; HADS-D = Hospital Anxiety and Depression Scale-Depression and IBDQ-32 = Inflammatory Bowel Disease Questionnaire-32.

Data availability statement

The data that support the findings of this study are available from the corresponding author, [S JM], upon reasonable request.