Enhanced systemic matrix metalloproteinase response in Helicobacter pylori gastritis

Figures & data

Table I.  Underlying diseases of the Helicobacter pylori-positive patients and the H. pylori-negative controls. No statistically significant differences in the presence of any of the underlying diseases were found between the two groups.

	Number of patients with underlying diseases
Underlying disease	H. pylori-positive patients (n=26)	H. pylori-negative controls (n=18)
Hypertension	7	8
Coronary artery disease	4	3
Atrial fibrillation	1	1
Hypercholesterolaemia	4	3
Diabetes type I	0	1
Diabetes type II, no complications	0	2
Diabetes type II, nephropathy	0	1
Bronchial asthma	3	4
Epilepsy	1	0
Sarcoidosis	1	0
Osteoarthritis	2	3
Rheumatoid arthritis	0	1
Osteoporosis	3	4
Migraine	1	0
Hiatal hernia, Barrett's oesophagus	0	1
Crohn's disease	0	1
Diverticular disease and irritable colon	2	2
Prostatic hyperplasia	2	1

Table II.  Characteristics of Helicobacter pylori-positive gastroscopied patients.

No	Sex	Age (y)	Indication for endoscopy	Erosions and ulcers	Chronic^a inflammation antrum/corpus	Acute^b inflammation antrum/corpus
1	F	56	coeliac disease?		3/2	1/1
2	M	68	dyspepsia		3/3	2/2
3	F	43	coeliac disease?		2/2	1/1
4	F	43	reflux		2/1	1/1
5	F	49	H. pylori resistance		3/2	1/1
6	F	79	anaemia		2/1	3/1
7	F	65	dyspepsia		3/2	2/2
8	F	64	reflux		2/2	1/1
9	F	80	reflux		3/2	1/1
10	F	57	dyspepsia	gastric ulcer	2/2	2/2
11	M	42	dyspepsia		2/1	1/1
12	M	77	weight loss		2/2	1/1
13	F	58	dyspepsia	gastric ulcer	2/1	1/1
14	M	71	reflux		2/1	1/0
15	M	82	anaemia	few^c erosions	2/2	0/2
16	F	58	dyspepsia		2/2	1/1
17	F	70	dyspepsia		2/3	0/2
18	F	70	H. pylori resistance		1/1	0/0
19	M	54	reflux		2/1	2/2
20	F	54	dyspepsia	few erosions	1/0	1/0
21	F	50	reflux		2/1	3/1
22	F	62	dyspepsia		2/1	1/1
23	F	73	dyspepsia		2/2	1/1
24	M	71	reflux		2/2	1/1
25	M	78	dyspepsia		3/1	2/2
26	F	66	dyspepsia	gastric ulcer	3/2	1/1

^aChronic (plasma cell/lymphocytic) inflammation was scored (0=none, 1=mild, 2=moderate, 3=severe) separately for antrum and corpus.

^bAcute (granulocytic) inflammation was scored (0=none, 1=mild, 2=moderate, 3=severe) separately for antrum and corpus.

^c1–5 macroscopical minimal erosions in the gastric mucosa.

Figure 1.  Serum levels of neutrophilic degranulation markers matrix metalloproteinase (MMP)-8 (A), MMP-9 (B), neutrophil elastase (NE) (C), and myeloperoxidase (MPO) (D) of 26 Helicobacter pylori gastritis patients and 18 H. pylori-negative controls with normal gastric mucosa. Data of two groups compared by the Mann-Whitney test. The horizontal line indicates median.

Figure 2.  Serum matrix metalloproteinase (MMP)-2 (A) and tissue inhibitor of metalloproteinase (TIMP)-1 (B) levels of 26 Helicobacter pylori gastritis patients and 18 H. pylori-negative controls with normal gastric mucosa. Data of two groups compared by the Mann-Whitney test. The horizontal line indicates median.