Figures & data
Figure 1. Survival curves of females fed with curcumin at the indicated phases of the lifespan. This is a composite graph of female longevities following curcumin feeding during the entire lifespan (N = 147, median lifespan = 36 days) or the untreated control (N = 230, median = 47) or in just one of the three different adult life stages. Comparing control to health (N = 126, median = 69, X2 = 127.7, and p < 0.0001); to transition (N = 126, median = 59, X2 = 59.4, and p < 0.0001); to senescent (N = 125, median = 39, X2 = 7.567, and p = 0.0059). Both sexes show the same stage-specific response in that only pre-midlife feedings (<42 days) increased lifespan relative to controls (from Soh et al. Citation2013).
Figure 2. Survival curves of females fed 10 mM NaBu at 21 days (start of transition span (<90 days)) or 42 days (start of senescent span (<80% survival)). The graph is rescaled so as to better show the late-life effects of NaBu. Both control vs. transition (log rank test, X2 = 52.98, 1 df, p < 0.0001) or control vs. senescent (X2 = 38.52, 1 df, p < 0.0001) are highly significant, but treatment starting with the transition span has a greater positive effect on late-life longevity than if given in later life (from McDonald et al. Citation2013).
