Influence of regression of left ventricular hypertrophy on left atrial size and function in patients with moderate hypertension

Figures & data

Table I. Demographic and clinical characteristics of patients at baseline.

	80 patients
Age (years)	53±10
Male/female	57/23
Height (cm)	170±14
Weight (kg)	86±17
Body mass index (kg/m^2)	26±3
Heart rate (beats/min)	77.6±12
Systolic blood pressure (mmHg)	157.5±5.1
Diastolic blood pressure (mmHg)	104.3±2.1
Interventricular septal thickness (cm)	1.21±0.17
Posterior wall thickness (cm)	1.08±0.10
Left ventricular mass (g)	230.8±46
Left ventricular end diastolic diameter (cm)	5.22±0.58
Ejection fraction (%)	61±8

Table II. Serial evaluation of clinical and echocardiographic parameters during the follow‐up.

Parameters	Baseline	3 months	6 months	12 months
SBP (mmHg)	142.5±5.1	130.5±4.3**	129.9±4.2**	128±3.7 **
DBP (mmHg)	93.3±2.1	89±1.3 *	87.4±2.5 **	86.1±2.1**
HR (beats/min)	77.6±12	75±9	76±10	75±9
LVMI	120.8±7	118.9±5	116.8±7	109±3**
E velocity	0.46±0.15	0.48±0.1	0.50±0.19	0.60±0.2**
A velocity	0.77±0.25	0.73±0.20	0.70±0.18 *	0.68±0.17**
E/A	0.59±0.2	0.65±0.19	0.71±0.18*	0.88±0.2*
MA dur (ms)	150±21	150±19	149±21	148±18
Dec t	230±34	228±27	217±21*	214±21**§
IVRT	110 ± 14	108 ± 12	106 ± 8*	105 ± 13**
Syst PVF	44±11.8	48±10.9	50±10.6	50±10.3*
Diast PVF	38±9.9	40±11	43±10.6	45±9.3*
PVA	26 ± 7.9	22 ± 6.8*	22 ± 5.7*	22 ± 7.4*
PA dur (ms)	176±20	164±19**	159±22**	155±20**

SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; LVMI, left ventricular mass index; E, peak early filling; A, atrial filling (A); MA dur, the duration of the mitral A wave; Dec t, deceleration time of peak E wave; IVRT, isovolumic relaxation time; Syst PVF, peak systolic forward velocity; Diast PVF, peak diastolic forward velocity; PVA, reversal wave peak flow velocity; PA dur, duration of the reversal wave during atrial contraction.

*p<0.05; **p<0.001 vs baseline; §p<0.001 vs 3 months.

Table III. Serial evaluation of left atrial volumes during the follow‐up.

Parameters	Baseline	3 months	6 months	12 months
LA antero‐posterior diameter (mm)	39±7	39±6	38±5	36±6*
LA supero‐inferior diameter (mm)	42±6	40±4	40±5	38±6*
Maximal volume (cm^3)	35±5	34±6	34±4	32±5*
P atrial volume (cm^3)	18±3	16±5	15±5	12±6*
Minimal volume (cm^3)	14±2	12±3.1	11±2	10±4
Conduit volume (cm^3)	34±4	33±5	32±2	31±6
Passive emptying volume (cm^3)	17±3	18±3.2	19±3	20±2.6
Active emptying volume (cm^3)	4±0.4	4±0.6	4±0.7	2±0.4*

LA, left atrium.

*p<0.05.

Table IV. Pearson's correlation of echocardiographic parameters with left ventricular mass index.

Parameter	r	p
LA maximal volume	0.45	0.01
LA minimal volume	0.34	0.05
LA P atrial volume	0.41	0.01
LA active emptying volume	0.39	0.01
LA total emptying volume	0.38	0.05

LA, left atrium.