Effects on plasma noradrenaline may explain some of the improved insulin sensitivity seen by AT‐1 receptor blockade

Figures & data

Figure 1 Study design.

Figure 2 Noradrenaline concentrations by the two treatment regimens.

Table I. Heart rate variability and baroreflex sensitivity (mean±SEM).

	Amlodipine 10 mg	Losartan 100 mg+amlodipine 5 mg	p‐value
Frequency domain
HF, normalized units (n.u.)	20.2±2.8	21.0±3.9	NS
LF, normalized units (n.u.)	27.3±3.1	25.6±3.0	NS
LF/HF ratio	2.08±0.37	2.02±0.33	NS
Time domain
MeanNN (ms)	765±22	734±24	NS
SDNN (ms)	136±9	116±9	NS
PNN50 (%)	5.63±1.65	4.29±1.56	NS
Baroreflex function
Baroreflex sensitivity (ms/mmHg)	9.7±0.9	10.7±1.4	NS

Frequency domain analysis in 20 patients during 5‐min sequences during a 40‐min supine rest. Time domain analysis measured during 24‐h Holter registration. Baroreflex sensitivity analysis during a 40‐min supine rest. HF; High frequency, LF; Low frequency, MeanNN; Mean R–R interval, NS; non‐significant, PNN50; the percentage of R‐intervals differing by >50 ms from the preceding interval, SDNN; standard deviation of all normal R–R intervals.