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Blood Pressure Volume 27, 2018 - Issue 2
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Original Article

Patterns of blood pressure response during intensive BP lowering and clinical events: results from the secondary prevention of small subcortical strokes trial

Elaine KuDivision of Nephrology, Department of Medicine, University of California, San Francisco, CAUSA; ;Division of Pediatric Nephrology, Department of Pediatrics, University of California, San Francisco, CA, USA; Correspondence[email protected]
View further author information
,
Rebecca ScherzerDivision of General Internal Medicine, Departments of Medicine, Epidemiology, and Biostatistics, San Francisco Veterans Affair Medical Center, University of California, San Francisco, CA, USA; View further author information
,
Michelle C. OddenCollege of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA; View further author information
,
Michael ShlipakDivision of General Internal Medicine, Departments of Medicine, Epidemiology, and Biostatistics, San Francisco Veterans Affair Medical Center, University of California, San Francisco, CA, USA; View further author information
,
Carole L. WhiteSPS3 Coordinating Center, University of British Columbia, Vancouver, BC, Canada; ;School of Nursing, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA; View further author information
,
Thalia S. FieldDivision of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, Canada; View further author information
,
Oscar BenaventeSPS3 Coordinating Center, University of British Columbia, Vancouver, BC, Canada; ;Division of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, Canada; View further author information
,
Pablo E. PergolaUniversity of Texas Health Sciences Center at San Antonio, San Antonio, TX, USAView further author information
&
Carmen A. PeraltaDivision of Nephrology, Department of Medicine, University of California, San Francisco, CAUSA; ;Division of General Internal Medicine, Departments of Medicine, Epidemiology, and Biostatistics, San Francisco Veterans Affair Medical Center, University of California, San Francisco, CA, USA; View further author information
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Pages 73-81 | Received 03 Jul 2017, Accepted 18 Sep 2017, Published online: 27 Sep 2017

Figures & data

Figure 1. Illustration of BP variability calculation1. For each observed BP measurement (xi), the deviation (di) is defined as the distance to the regression line, or the absolute value of the residual (observed minus predicted value).

1Deviation variables were calculated as follows:

Figure 1. Illustration of BP variability calculation1. For each observed BP measurement (xi), the deviation (di) is defined as the distance to the regression line, or the absolute value of the residual (observed minus predicted value).1Deviation variables were calculated as follows:

Table 1. Summary of candidate BP measures selected a priori for the derivation of cluster membership (among SPS3 participants in lower SBP target group).

Figure 2. Association of baseline SBP with SBP variability, stratified by cluster membership. Blue open circles and solid line denote cluster 1. Red plus symbols and dashed line denote cluster 2. Green x symbols and dash/dot line denote cluster 3. Elliptical curves denote 95% confidence regions for each cluster.

Figure 2. Association of baseline SBP with SBP variability, stratified by cluster membership. Blue open circles and solid line denote cluster 1. Red plus symbols and dashed line denote cluster 2. Green x symbols and dash/dot line denote cluster 3. Elliptical curves denote 95% confidence regions for each cluster.

Table 2. Baseline characteristics of SPS3 participants by cluster stratified by lower and higher BP target groups.

Table 3. Association of cluster with outcomes in SPS3 participants (among participants in the lower BP target group).

Supplemental material

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