Retinal vascular resistance in arterial hypertension

Figures & data

Figure 1. Retinal sample in the juxtapapillary area of a study participant.

Table 1. Clinical parameters.

	Normotensive patients	Hypertensive patients
Clinical parameters	n = 45	n = 123	p value
age [yrs]	41.1 ± 11.5	52.9 ± 11.9	<.001
office SBP [mmHg]	133 ± 12	148 ± 10	<.001
office DBP [mmHg]	81.3 ± 8.0	93.4 ± 7.6	<.001
BMI [kg/m^2]	30.9 ± 3.4	28.4 ± 3.2	<.001
triglycerides [mg/dl]	152 ± 104	156 ± 103	.74
total cholesterin [mg/dl]	219 ± 38	220 ± 39	.87
HDL [mg/dl]	51.9 ± 12.1	48.0 ± 10.7	.03
LDL [mg/dl]	147 ± 29	151 ± 34	.46
UACR [mg/g creatinine]	4.28 (2.73-8.96)	6.00 (4–11)	.09
Serum creatinine [mg/dl]	0.93 ± 0.1	0.96 ± 0.2	.31
MAP [mmHg]	107 ± 8.9	121 ± 6.7	<.001

Quantitative values are expressed as mean ± standard deviation; MAP- mean arterial pressure, SBP –systolic blood pressure, DBP-diastolic blood pressure, BMI – body mass index, UACR- urine albumin-to-creatinine ratio.

Table 2. Retinal parameters.

	Normotensive patients	Hypertensive patients
Retinal parameters	n = 45	n = 123	p value
Retinal Capillary Flow (RCF) [AU]	319 ± 63	302 ± 95	.023
Retinal Vascular Resistance (RVR) [mmHg/AU]	0.31 ± 0.06	0.41 ± 0.13	<.001
Vessel diameter (OD) [µm]	108 ± 11	104 ± 15	.06
Lumen diameter (ID) [µm]	81.4 ± 8.2	76.6 ± 8.3	.001
Wall thickness (WT) [µm]	13.7 ± 3.5	13.5 ± 4.2	.67
Wall/Lumen Ratio (WLR)	0.34 ± 0.08	0.35 ± 0.10	.41
Cross Section Area (WCSA)[µm^2]	4142 ± 1381	3896 ± 1578	.23

Quantitative values are expressed as mean ± standard deviation.

Figure 2. Retinal vasculare resistance (RVR) in normotensive and hypertensive subjects (boxplot illustration).

Figure 3. Correlation of RVR with wall to lumen ratio in retinal arterioles (r = 0.271, p < .001).