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Original Article

The usefulness of a single arm cuff oscillometric method (Arteriograph) to assess changes in central aortic blood pressure and arterial stiffness by antihypertensive treatment: results from the Doxazosin-Ramipril Study

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Pages 88-98 | Received 29 Jun 2017, Accepted 16 Oct 2017, Published online: 26 Oct 2017

Figures & data

Figure 1. Comparison of the single cuff oscillometric cuff method (Arteriograph) and pulse wave analysis with applanation tonometry (SphygmoCor) concerning systolic aortic BP (SBP) (a), diastolic aortic BP (DBP) (b), aortic pulse pressure (PP) (c), aortic mean arterial pressure (MAP) (d), augmentation index (AIx) (e), and pulse wave velocity (PWV) (f).

Figure 1. Comparison of the single cuff oscillometric cuff method (Arteriograph) and pulse wave analysis with applanation tonometry (SphygmoCor) concerning systolic aortic BP (SBP) (a), diastolic aortic BP (DBP) (b), aortic pulse pressure (PP) (c), aortic mean arterial pressure (MAP) (d), augmentation index (AIx) (e), and pulse wave velocity (PWV) (f).

Table 1. Comparison of measurements by applanation tonometry with SphygmoCor and by oscillometric cuff method with Arteriograph.

Figure 2. Bland-Altman analyses of the difference in mean values obtained by the single cuff oscillometric cuff method (Arteriograph) and by pulse wave analysis with applanation tonometry (SphygmoCor). Systolic aortic BP (SBP) (a), diastolic aortic BP (DBP) (b), aortic pulse pressure (PP) (c), aortic mean arterial pressure (MAP) (d), augmentation index (AIx) (e), and pulse wave velocity (PWV) (f).

Figure 2. Bland-Altman analyses of the difference in mean values obtained by the single cuff oscillometric cuff method (Arteriograph) and by pulse wave analysis with applanation tonometry (SphygmoCor). Systolic aortic BP (SBP) (a), diastolic aortic BP (DBP) (b), aortic pulse pressure (PP) (c), aortic mean arterial pressure (MAP) (d), augmentation index (AIx) (e), and pulse wave velocity (PWV) (f).

Table 2. Baseline data for 58 patients treated with doxazosin or ramipril.

Table 3. Treatment effects on blood pressure and vascular function measures by the cuff based oscillometric technique; univariate and multivariate analyses.

Figure 3. Relative changes in BP and vascular function by treatment, presented as mean values ± SEM. SBP: systolic blood pressure; DBP: diastolic blood pressure; AIx: augmentation index; PWV: pulse wave velocity. Absolute changes for doxazosin and ramipril were −4.2 ± 3.0 and −17.1 ± 2.3 mm Hg for brachial SBP, −4.3 ± 3.4 and −20.9 ± 2.7 mm Hg for aortic SBP, −3.4 ± 1.4 and −10.7 ± 1.6 mm Hg for brachial DBP, −2.7 ± 1.5 and −10.8 ± 1.5 mm Hg for aortic DBP, −2.2 ± 1.4 and −6.2 ± 1.6% for AIx, −0.6 ± 0.2 and −0.4 ± 0.2 m/s for PWV, and 3.2 ± 1.5 and 4.2 ± 1.6 ms for transit time, respectively. Significance values for univariate analyses are denoted as *p < .05,**p < .01, and ***p < .001. Multivariate analyses are presented in .

Figure 3. Relative changes in BP and vascular function by treatment, presented as mean values ± SEM. SBP: systolic blood pressure; DBP: diastolic blood pressure; AIx: augmentation index; PWV: pulse wave velocity. Absolute changes for doxazosin and ramipril were −4.2 ± 3.0 and −17.1 ± 2.3 mm Hg for brachial SBP, −4.3 ± 3.4 and −20.9 ± 2.7 mm Hg for aortic SBP, −3.4 ± 1.4 and −10.7 ± 1.6 mm Hg for brachial DBP, −2.7 ± 1.5 and −10.8 ± 1.5 mm Hg for aortic DBP, −2.2 ± 1.4 and −6.2 ± 1.6% for AIx, −0.6 ± 0.2 and −0.4 ± 0.2 m/s for PWV, and 3.2 ± 1.5 and 4.2 ± 1.6 ms for transit time, respectively. Significance values for univariate analyses are denoted as *p < .05,**p < .01, and ***p < .001. Multivariate analyses are presented in Table 3.
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