Figures & data
Table 1. Baseline characteristics, stratified by age and hypertensive phenotype. Data are presented as mean (SD), median [IQR] or n (%). BP: blood pressure; BMI: body mass index, CV: cardiovascular, SAS: South-Asian Surinamese, AS: African Surinamese. NT: normotensive, ISH: isolated systolic hypertension, IDH: isolated diastolic hypertension, SDH: systolic and diastolic hypertension. *Fasting glucose was missing in 45 participants (0.4%), in which case diabetes status was based on medication use.
Figure 1: Relation between age and xBRS, SDNN, RMSDD for different hypertensive phenotypes. Lines depicted estimates from linear regression model with correction for BMI (visualized for the population mean BMI of 27.6 kg/m2), diabetes, BP-lowering medication use and beta-blockers, shaded area indicate 95% confidence interval. xBRS: cross-correlation baroreflex sensitivity, SDNN: standard deviation of normal-to-normal intervals, RMSDD: the squared root of the mean squared successive difference between adjacent normal-to-normal intervals.
Table 2. Differences in xBRS and HRV between phenotypes as determined using linear regression models with correction for age, ethnicity, BMI, diabetes, BP-lowering drugs and beta-blockers. Coef. denotes coefficient from linear regression model, values for xBRS were log transformed prior to analyses and the coefficients depict ratio. xBRS: cross-correlation baroreflex sensitivity, SDNN standard deviation of normal-to-normal intervals, RMSDD: the squared root of the mean squared successive difference between adjacent normal-to-normal intervals. NT: normotensive, ISH: isolated systolic hypertension, IDH: isolated diastolic hypertension; SDH: systolic and diastolic hypertension, est: estimate, p-val: p-value.
Supplemental Material
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The HELIUS data are owned by the Amsterdam UMC, location AMC in Amsterdam, the Netherlands. Any researcher can request the data by submitting a proposal as outlined at http://www.heliusstudy.nl/.