Understanding ocular comfort differences between 0.7% olopatadine and 0.3% pheniramine maleate/0.025% naphazoline hydrochloride eye drops

Figures & data

Table 1. Between drop signs comparisons before and after drop instillation.

Clinical Test	Baseline Pataday (Mean ± SD)	Baseline Visine (Mean ± SD)	Post-Drop Pataday (Mean ± SD)	Post-Drop Visine (Mean ± SD)	p-Value (Baseline Pataday vs. Baseline Visine)	P-Value (Post-Drop Pataday vs. Post-Drop Visine)	P-Value (Baseline Vs. Post-Drop Pataday)	P-Value (Baseline Vs. Post-Drop Pataday)
Visual Acuity (LogMAR)	−0.08 ± 0.12	−0.07 ± 0.14	−0.06 ± 0.11	−0.07 ± 0.13	0.17	0.40	<0.001	0.72
Bulbar Redness*
Nasal (0–4scale)	0.69 ± 0.31	0.66 ± 0.30	0.59 ± 0.26	0.39 ± 0.20	0.10	<0.001	<0.001	<0.001
Temporal (0–4 scale)	0.65 ± 0.26	0.66 ± 0.26	0.59 ± 0.24	0.45 ± 0.20	0.25	<0.001	<0.001	<0.001
Limbal Redness*
Nasal (0–4 scale)	0.38 ± 0.25	0.36 ± 0.23	0.33 ± 0.21	0.20 ± 0.18	0.12	<0.001	<0.001	<0.001
Temporal (0–4 scale)	0.35 ± 0.22	0.35 ± 0.22	0.32 ± 0.23	0.21 ± 0.18	0.58	<0.001	<0.001	<0.001

*Larger redness scores indicate worse redness.

Table 2. Comfort visual analog scale by allergy drop and instillation time.

Time Point	Pataday (Mean ± SD)	VISINE (Mean ± SD)	Difference (Mean ± SD)	p-Value
Baseline	94.1 ± 6.8	94.0 ± 7.1	0.1 ± 1.6	0.30
Instillation	80.8 ± 20.2	74.5 ± 23.4	6.3 ± 21.5	<0.001
30 Seconds	85.6 ± 16.3	76.2 ± 21.7	9.4 ± 21.1	<0.001
1 Minute	90.0 ± 12.7	83.7 ± 16.8	6.3 ± 15.4	<0.001
2 Minutes	93.0 ± 10.9	88.5 ± 14.4	4.4 ± 14.9	<0.001

*Higher comfort scores indicate more comfortable eyes.

Figure 1. Likert question responses by allergy eye drop.