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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 36, 2007 - Issue 3
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MHC-Restricted Presentation of a Single Repeat of MUC1 Mucin

Melody K. Orr Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
,
Janet S. Burnside Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
,
Catherine A. Phillips Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Cell Biology and Biochemistry; Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA; Veterans Affairs Medical Center, Amarillo, Texas, USA
,
Ramila Philip Departments of Molecular Biology and Cancer Biology, RPR GenCell, Inc. (formerly Applied Immune Sciences, Inc., (AIS)), Santa Clara, California, USA
,
Kenneth E. Dombrowski Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Veterans Affairs Medical Center, Amarillo, Texas, USA; Department of Veterans Affairs and the Atlanta Research and Education Foundation, Decateur, Georgia, USA; Departments of Microbiology/Immunology, Emory University School of Medicine, Atlanta, Georgia, USA
&
Stephen E. Wright Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Cell Biology and Biochemistry; Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA; Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Veterans Affairs Medical Center, Amarillo, Texas, USACorrespondence[email protected]
Pages 271-283 | Published online: 07 Jul 2009
 
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Abstract

Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1 peptide presented by allogeneic (MHC-independent) or autologous (MHC-dependent) Epstein-Barr Virus (EBV) immortalized B lymphocytes. The ability to generate greater CTL activity against MUC1-expressing tumor cells by stimulation with autologous versus allogeneic EBV-B supports the hypothesis that presentation of a single repeat of MUC1 peptide is MHC-restricted (MHC-dependent).

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