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International Reviews of Immunology Volume 25, 2006 - Issue 3-4
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Special Topic: DNA Vaccines

Ex Vivo Programming of Antigen-Presenting B Lymphocytes: Considerations on DNA Uptake and Cell Activation

Matthew Wheeler The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USA
,
Xotchil Cortez-Gonzalez The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USA
,
Raffaele Frazzi The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USA
&
Maurizio Zanetti The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USACorrespondence[email protected]
Pages 83-97 | Published online: 03 Aug 2009
 
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Abstract

Plasmids used in DNA vaccination not only serve as a source of antigen, but also have an important adjuvant effect. This review focuses on recent advancements made in understanding how cells internalize DNA, and how internalized DNA activates immune response pathways. We also comment on the role of B cells in both of these processes.

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