Osteoprotegerin and Bone Mineral Density in Hemodiafiltration Patients

Figures & data

Table 1. Baseline subjects characteristics (mean ± SEM)

	Hemodiafiltration	Control
Age (years)	65 ± 2.3	61 ± 2
Males	15	15
Females	21	21
Duration of menopause (years)	19 ± 2.5	17 ± 2
Body mass index (kg/m^2)	24 ± 2.3	23 ± 0.5
Duration of HD (months)	40.76 ± 7.58	—

Table 2. Biochemical and bone mineral density data of HDF patients and controls (mean ± SEM)

	Hemodiafiltration	Control	p
Ca (mmol/L)	2.75 ± 0.26	2.58 ± 0.02	< 0.05
P (mmol/L)	1.62 ± 0.08	1.25 ± 0.025	< 0.001
B-ALP (UI/L)	121 ± 15.7	76.8 ± 4.17	< 0.01
BGP (mmol/L)	22 ± 4.05	4.9 ± 0.25	< 0.001
IGF-1 (nmol/L)	20.17 ± 1.8	14.9 ± 0.61	< 0.005
Vitamin D3 (nmol/L)	109.82 ± 7.48	117.312 ± 6.24	ns
iPTH (pmol/L)	238 ± 26.08	50 ± 2.83	< 0.001
17β-estradiol (pmol/L)	77.09 ± 2.46	74.88 ± 066	ns
Free testosterone (pmol/L)	19.91 ± 2.49	26.02 ± 2.88	ns
OPG (pmol/L)	14 ± 0.88	5.7 ± 0.32	< 0.001
Spine (g/cm^2)	1.06 ± 0.042	0.994 ± 0.018	ns
Femur neck (g/cm^2)	0.73 ± 0.023	0.81 ± 0.027	< 0.05
Intertrochanteric (g/cm^2)	0.95 ± 0.02	1.043 ± 0.27	< 0.005
Trochanteric (g/cm^2)	0.58 ± 0.022	0.68 ± 0.033	< 0.05
Ward triangle (g/cm^2)	0.52 ± 0.023	0.61 ± 0.032	< 0.05
BUA (dB/MHz)	102 ± 3.68	111 ± 1.06	< 0.05
SOS (m/s)	1511 ± 4.96	1529 ± 4.5	< 0.01
AD-SOS (m/s)	1801 ± 19	1895 ± 14.5	< 0.001
UBPI	0.22 ± 0.025	0.3 ± 0.022	< 0.01

Table 3. Biochemical, bone mineral density, and ultrasound data of HDF patients grouped according to PTH > or < 150 pg/mL (mean ± SEM)

	iPTH < 150 (21)	iPTH > 150 (15)	p
B-ALP (UI/L)	79 ± 11.29	173 ± 29.98	< 0.005
BGP (ng/mL)	8.5 ± 0.91	40.96 ± 7.44	< 0.001
IGF-1 (nmol/L)	19.38 ± 2.35	21.2 ± 3.1	ns
Vitamin D3 (nmol/L)	104.83 ± 14.91	117.31 ± 7.48	ns
Spine (g/cm^2)	1.048 ± 0.105	1.074 ± 0.140	ns
Femur neck (g/cm^2)	0.728 ± 0.037	0.727 ± 0.032	ns
Intertrochanteric (g/cm^2)	0.949 ± 0.027	0.955 ± 0.034	ns
Trochanteric (g/cm^2)	0.569 ± 0.026	0.602 ± 0.041	ns
Ward triangle (g/cm^2)	0.516 ± 0.034	0.526 ± 0.033	ns
BUA (dB/MHz)	103.8 ± 5.1	99.75 ± 6.09	ns
SOS (m/s)	1516 ± 4.6	1504 ± 10.56	ns
AD-SOS (m/s)	1784.4 ± 18.87	1821.25 ± 39.96	ns
UBPI	0.19 ± 0.025	0.26 ± 0.05	ns

Table 4. Biochemical, bone mineral density, and ultrasound data of HDF patients grouped according to OPG < and > 14 pmol/L (mean ± SEM)

	OPG < 14 pmol/L	OPG > 14 pmol/L	p
Number of patients	21 HD	15 HD
Ca (mmol/L)	2.73 ± 0.18	2.78 ± 0.2	ns
B-ALP (UI/L)	101.4 ± 26.06	145.5 ± 14.65	ns
BGP (ng/mL)	23 ± 5.6	20 ± 6.5	ns
IGF-1 (nmol/L)	25.05 ± 2.46	14.45 ± 1.94	< 0.005
Vitamin D3 (nmol/L)	132.13 ± 9.38	83.11 ± 9.63	< 0.001
Spine (g/cm^2)	1.156 ± 0.06	0.911 ± 0.03	< 0.005
Femur neck (g/cm^2)	0.759 ± 0.037	0.682 ± 0.025	ns
Intertrochanteric (g/cm^2)	0.967 ± 0.03	0.929 ± 0.02	ns
Trochanteric (g/cm^2)	0.627 ± 0.034	0.516 ± 0.054	< 0.01
Ward triangle (g/cm^2)	0.582 ± 0.031	0.426 ± 0.015	< 0.001
BUA (dB/MHz)	98.57 ± 4.42	114 ± 8.4	ns
SOS (m/s)	1509 ± 6.6	1517 ± 10	ns
AD-SOS (m/s)	1794 ± 28	1824 ± 11	ns
UBPI	0.21 ± 0.037	0.25 ± 0.016	ns

Table 5. Biochemical, bone mineral density, and ultrasound data of HDF patients grouped according to combinations of OPG and PTH (mean ± SEM)

	Group A	Group B	Group C	Group D
Patient number	9	6	12	9
OPG	< 14 pmol/L	> 14 pmol/L	< 14 pmol/L	> 14 pmol/L
iPTH	> 150 pg/mL	> 150 pg/mL	< 150 pg/mL	< 150 pg/mL
B-ALP (IU/mL)	170 ± 47.33	177 ± 3.47	55.67 ± 6.49,	114 ± 24.98,
BGP (ng/mL)	39.43 ± 11.99	43.25 ± 10.94	11.32 ± 0.57,	4.73 ± 1.01,
IGF-1 (nmol/L)	28.03 ± 3.55	10.96 ± 0.02	22.08 ± 3.85	16.8 ± 3.21
Vitamin D3 (nmol/L)	127.22 ± 11.10	112.44 ± 12.9	135.8 ± 15.57	63.57 ± 9.70,,
Spine (g/cm^2)	1.25 ± 0.11	0.89 ± 0.033	1.107 ± 0.083	0.93 ± 0.06
Femur neck (g/cm^2)	0.82 ± 0.03	0.63 ± 0.02	0.73 ± 0.06	0.73 ± 0.05
Trochanteric (g/cm^2)	0.69 ± 0.06	0.51 ± 0.016	0.594 ± 0.042	0.52 ± 0.003
Ward triangle (g/cm^2)	0.63 ± 0.02	0.42 ± 0.02	0.558 ± 0.05	0.43 ± 0.03
BUA (dB/MHz)	103 ± 9.3	91 ± 5.3	95 ± 4.7	93 ± 5.67
SOS (m/s)	1510 ± 16	1489 ± 9.8	1509 ± 4.5	1505 ± 12
AD-SOS (m/s)	1831 ± 13	1793 ± 23	1767 ± 26	1796 ± 28
UBPI	0.27 ± 0.023	0.21 ± 0.033	0.16 ± 0.032 +	0.22 ± 0.03

^*p < 0.05 vs. A.

^†p < 0.05 vs. B.

^‡p < 0.05 vs. C.