An Association Between Inflammatory State and Left Ventricular Hypertrophy in Hemodialysis Patients

Figures & data

Table 1. Left ventricular characteristics of hemodialysis patients by echocardiography

Characteristics	LVH ( + ) patients (n = 20)	LVH ( − ) patients (n = 15)	P
LVMI (g/m2)	183.6 ± 55	107 ± 16.4	0.001
PWT (mm)	13.9 ± 2.1	11.5 ± 1.2	0.001
IVS (mm)	15.4 ± 3.6	12.3 ± 1.4	0.001
LVEDD (mm)	50.9 ± 3.9	45.7 ± 4.5	0.001
LVESD (mm)	32.8 ± 4.4	27.8 ± 3.8	0.006
Ejection fraction (%)	63.2 ± 8.3	65 ± 9.7	NS
Fractional shortening (%)	35.1 ± 4.9	37.8 ± 4	NS

Data expressed as mean ± SD. Abbreviations: LVMI: left ventricular mass index; PWT: posterior wall thickness; IVS: interventricular septum thickness; LVEDD: left ventricular end diastolic diameter, LVESD: left ventricular end systolic diameter

Table 2. Clinical and laboratory characteristics of HD patients with and without LVH

Characteristics	LVH ( + ) patients (n = 20)	LVH ( − ) patients (n = 15)	P
Age	44 ± 16	47 ± 15	NS
Gender (men/women)	13/7	12/3	NS
HD duration (mo)	41 ± 35	36 ± 34	NS
Antihypertensive drug user (n)	11	3	0.04
Ertyropoietin (n)	11	11	NS
Body mass index (kg/m^2)	22.1 ± 2.7	23.4 ± 4.2	NS
Urea reduction ratio (%)	57 ± 10.7	56.1 ± 6.9	NS
Interdialytic weight gain (kg)	2.33 ± 1.17	2.17 ± 1.90	NS
Systolic BP (mm Hg)	127 ± 18	118 ± 15	NS
Diastolic BP(mm Hg)	75 ± 12	72 ± 9.4	NS
Hemoglobin (g/dL)	10.8 ± 1.8	11 ± 1.3	NS
Albumin (g/dL)	3.95 ± 0.34	3.97 ± 0.21	NS
Ferritin (ng/mL)	316 ± 244	265 ± 264	NS
IPTH (pmol/L)	16.8 ± 11.05	18.7 ± 12.2	NS
Calcium (mmol/L)	8.8 ± 0.5	8.77 ± 1	NS
Phosphate (mmol/L)	6.1 ± 1.7	4.7 ± 1.6	NS
Total cholesterol (mg/dL)	161 ± 40	154 ± 31	NS
HDL cholesterol (mg/dL)	35 ± 12	33 ± 7	NS
LDL cholesterol (mg/dL)	95 ± 40	86 ± 25	NS
IL-1 β (pg/mL)	10.5 ± 0.9	11.2 ± 2.6	NS
IL-6 (pg/mL)	16.4 ± 9.5	14.6 ± 7.5	NS
TNF-α (pg/mL)	8.9 ± 3.5	7.4 ± 2	NS
THcy (pg/mL)	24.8 ± 8.2	23.5 ± 6.9	NS

Table 3. Mean serum levels of IL-1 β, IL-6, TNF-α, and tHcy in HD patients (before and after HD) and healthy subjects

	Patients (n = 35) before HD	Patients (n = 35) after HD	Healthy subjects (n = 12)
IL-1 β (pg/mL)	10.8 ± 1.8	11 ± 1.9	10.2 ± 0.98
IL-6 (pg/mL)	15.7 ± 8.7,	17.8 ± 9.5	7.3 ± 0.7
TNF-α (pg/mL)	8.3 ± 3	9.9 ± 3.5	7 ± 1.45
THcy (pg/mL)	24.2 ± 7.6,	18.9 ± 5.9	8.7 ± 1.6

^*p< 0,05 vs. control.

^†p< 0,05 vs. after dialysis.

Figure 1 Correlation between systolic BP and LVMI (r = 0.556, p = 0.001).

Figure 2 Correlation between diastolic BP and LVMI (r = 0.474, p = 0.004).

Figure 3 Correlation between predialysis TNF-α level and LVMI (r = 0.446, p = 0.009)