Transforming Growth Factor-β1 Gene Polymorphism in Renal Transplant Recipients

Figures & data

Table 1. Baseline demographic and clinical characteristics

	Leu/Leu (N = 21)*	Leu/Pro or Pro/Pro (N = 108)*	p Value
Patient-related factors
Age of kidney recipients (years)	35 ± 10 (16–61)	36 ± 9 (13–58)	0.54
Systolic blood pressure (mmHg)	130 ± 18	132 ± 16	0.57
Diastolic blood pressure (mmHg)	83 ± 11	81 ± 11	0.50
Number of antihypertensive drugs	1.5 ± 0.9 (0–3)	1.2 ± 0.9 (0–4)	0.21
Diabetes mellitus	2 (10%)	8 (7%)	0.91
Recipient body weight at 1 year (kg)	59.4 ± 10.8	59.0 ± 10.7	0.88
Graft-related factors
Age of kidney donors (years)	35 ± 14 (12–59)	36 ± 12 (9–63)	0.58
Living kidney donors	7 (33%)	37 (34%)	0.72
Cold ischemic time (hours)	8.4 ± 11.7	9.0 ± 9.0	0.83
HLA incompatibility (number of mismatch)	2.7 ± 1.4	2.5 ± 1.4	0.44
Symptomatic cytomegalovirus infection (number of patients)	1 (5%)	9 (8%)	1.00
Laboratory values
Glomerular filtration rate (mL/min/1.73 m^2 of body surface area) by MDRD equation at 1 year	55 ± 20	49 ± 16	0.16
Dose of cyclosporine (mg per kg body weight) at 1 year	4.1 ± 1.5	4.2 ± 1.3	0.86
Serum albumin (g/L) at 1 year	41 ± 3	40 ± 4	0.07
Last available trough cyclosporine level (μg/L)	149 ± 51	142 ± 54	0.65

*Plus-minus values are mean ± SD (ranges) unless otherwise indicated.

Table 2. Incidence and histopathologic findings of acute rejection

	Leu/Leu (N = 8)*	Leu/Pro or Pro/Pro (N = 44)*	p Value
Number of rejection episodes per patient
1	6	29
2	1	12	0.89
3	1	1
4	0	1
Average cellular infiltration (percentage of parenchyma affected)	20 ± 8	20 ± 9	0.86
Banff 97 diagnostic classification of acute rejection:
Borderline	5 (63%)	28 (63%)
Grade I	2 (25%)	8 (18%)	0.76
Grade II	0 (0%)	2 (5%)
Grade III	1 (13%)	6 (14%)

*Plus-minus values are mean ± SD (ranges) unless otherwise indicated.

Figure 1. Leu/Leu (TT) genotype associated with greater decline in glomerular filtration rate. Boxes show the median values, the first and third quartiles in each group.