Relation of Thyroid Disfunction, Thyroid Autoantibodies, and Renal Function

Figures & data

Table 1. Characteristics of patients

	Hypothyroidism	Hyperthyroidism	Control subjects
No. of patients	41	17	27
Mean of age	43.5 ± 12.3	34.4 ± 9.5	48.7 ± 11.9
Male	7	9	13
Female	34	8	14

Table 2. Association of thyroid autoantibody with UAER and CC

	TAA positive	TAA negative	P value
Mean UAER (mg/day)	30.2	20.8	= 0.05
Mean CC (mL/min)	79.8	82.1	NS
Prevalence of microalbuminuria	31.8%	22.2%	NS

TAA, thyroid autoantibodies; UAER, urinary albumin excretion rate; CC, creatinine clearance; NS, not significant.

Table 3. Relation between thyroid functional status with UAER and CC

	Hypothyroidism	Hyperthyroidism	Control	P value
Mean UAER (mg/day)	30.1,#	11.8	10.5	< 0.001
Mean CC (mL/min)	79.0**	86.5	84.1	= 0.02
Prevalence of microalbuminuria	36.6%	0%	0%

UAER, urinary albumin excretion rate; CC, creatinine clearance.

^#p < 0.001 for the comparison with control.

*p < 0.001 vs. hyperthyroid patients.

**p < 0.01 vs. hyperthyroid patients.

Table 4. Association of thyroid autoantibody (TAA) with UAER and CC in hypothyroid population

	TAA positive	TAA negative	P value
Mean UAER (mg/day)	32.9	27.9	NS
Mean CC (mL/min)	79.3	78.8	NS
Prevalence of microalbuminuria	46.7%	53.3%	NS

TAA, thyroid autoantibodies; UAER, urinary albumin excretion rate; CC, creatinine clearance; NS, not significant.