Angiotensin II and Endothelin in the Renal Cortex During the Evolution of Glycerol-Induced Acute Tubular Necrosis

Figures & data

Table 1. Score for endothelin staining in cortical tubulointerstitium and number of AII-positive cells per grid field of renal cortex measuring 0.245 mm² from control rats (C) and from rats killed 5 (G-5 days), 30 (G-30 days), and 60 days (G-60 days) after glycerol (G) injection

Groups	Endothelin	AII^+ cells
C (N = 6)	0.55 ± 0.06	0.72 ± 0.11
G-5 days (N = 8)	1.81 ± 0.13***	20.41 ± 1.95***
G-30 days (N = 8)	1.75 ± 0.15***	9.77 ± 1.13***,###
G-60 days (N = 9)	1.46 ± 0.14***	7.46 ± 0.77***,###

Data are expressed as mean ± SEM.

***P < 0.001 vs. control.

^###P < 0.001 vs. G-5 days.

Figure 1. Immunolocalization of endothelin in the renal cortex from a control rat (A) and from rats killed 5 (B) and 30 days (C) after glycerol injection. Observe that the immunoreaction for endothelin is more intense in glycerol-injected rats (B and C) than in the control animal (A). × 280.

Figure 2. Immunolocalization of AII in the renal cortex from a control rat (A) and from rats killed 5 (B) and 30 days (C) after glycerol injection. Note that the number of AII-positive cells is higher in B and C than in A. × 280.