Urinary Excretion of Guanidinoacetic Acid in Rats with Diabetic Nephropathy

Figures & data

Table 1 Serum glucose and creatinine levels in diabetic nephropathy and control rats

	Glucose (mg/dL)		Creatinine (mg/dL)
	Control	Diabetes	Control	Diabetes
Week 0	122.3 ± 5.6	110.5 ± 5.7	0.57 ± 0.07	0.55 ± 0.05
Week 1	112.2 ± 4.6	265.1 ± 23.5	0.62 ± 0.02	0.51 ± 0.03
Week 2	133.4 ± 4.6	333.0 ± 15.7	0.64 ± 0.02	0.64 ± 0.02
Week 3	101.8 ± 2.3	400.7 ± 23.4	0.64 ± 0.02	0.58 ± 0.05

Mean ± SE.

*p < 0.001.

Figure 1. Urinary and serum guanidinoacetic acid (GAA) concentrations in the control and diabetic rats. mean ± SE, *p < 0.001, **p < 0.01.

Figure 2. Renal cortical guanidinoacetic acid (GAA) concentrations in streptozotocin-induced diabetic rats. mean ± SE, *p < 0.01, **p < 0.05.

Figure 3. Urinary N-acetyl-β-D-glucosaminidase (NAG) levels in the control and diabetic rats. mean ± SE, *p < 0.001, **p < 0.01.

Figure 4. The effect of insulin on urinary and serum guanidinoacetic acid (GAA) concentrations in diabetic rats. mean ± SE, *p < 0.001, **p < 0.01.

Figure 5. The effect of insulin on renal cortical guanidinoacetic acid (GAA) concentrations in diabetic rats. mean ± SE, *p < 0.001, **p < 0.05.