The Importance of Glomerular Deposits of Von Willebrand Factor in Human Renal Allografts

Figures & data

Figure 1 WF staining in the endothelium of the capillary loops.

Figure 2 vWF staining in the glomerular subendothelium.

Figure 3 Global mesangial vWF staining in the glomerulus.

Figure 4 CD68 positive macrophages were noted in the glomerulus.

Table 1 Correlation of glomerular vWF (GvWF) expression with the type of AR

	AR type 1		AR type 2
	n	%	n	%
GvWF 1	8	53.3	7	46.7
GvWF 2	10	58.8	7	41.2
GvWF 3	0	0	8	100

P < 0.01.

Figure 5 Both subendothelial and segmental mesangial vWF staining were observed in the glomerulus.

Table 2 Relationship of glomerular vWF (GvWF) expression and glomerular macrophage (GM) infiltration in patients with AR

	GM 0		GM 1		GM 2
	n	%	n	%	n	%
GvWF 1	6	40	6	40	3	20
GvWF2	3	17.6	11	64.8	3	17.6
GvWF3	0	0	2	25	6	75

P < 0.05.

Table 3 Influence of glomerular vWF (GvWF) expression on the development of glomerular sclerosis (GS) in follow-up biopsies in patients with AR

	GS (−)		GS (+)
	n	%	n	%
GvWF 1	12	80	3	20
GvWF 2	9	52.9	8	47.1
GvWF 3	1	12.5	7	87.5

P < 0.01.

Table 4 Relationship between glomerular vWF (GvWF) expression and graft outcome in patients with AR

	Stable RF		Deteriorated RF		Graft loss
	n	%	n	%	n	%
GvWF 1	7	46.6	4	26.7	4	26.7
GvWF 2	3	17.6	10	58.8	4	23.6
GvWF 3	0	0	0	0	8	100

RF: Renal function, P < 0.001.

Table 5 Correlation of glomerular vWF (GvWF) expression with grade of CAN

	CAN Grade 1		CAN Grade 2		CAN Grade 3
	n	%	n	%	n	%
GvWF 1	2	100	0	0	0	0
GvWF 2	3	21.4	7	50	4	28.6
GvWF 3	3	18.7	7	43.8	6	37.5

Table 6 Relationship of glomerular vWF (GvWF) expression and glomerular macrophage (GM) infiltration in patients with CAN

	GM 0		GM 1		GM 2
	n	%	n	%	n	%
GvWF 1	2	100	0	0	0	0
GvWF 2	5	35.7	7	50	2	14.3
GvWF 3	1	6.3	3	18.7	12	75

P = 0.001.

Table 7 Expression of glomerular vWF expression in patients with AR and CAN

	AR		CAN
	n	%	n	%
GvWF 1	15	88.2	2	11.8
GvWF 2	17	54.8	14	45.2
GvWF 3	8	33.3	16	66.7

P = 0.001.