A Role for Erythropoietin in the Attenuation of Radiocontrast-Induced Acute Renal Failure in Rats

Figures & data

Table 1 Functional parameters in the two experimental groups

Variable		CTR (n = 11)	EPO (n = 11)
Urine volume (mL/hour)	Day 0	0.40 ± 0.04	0.32 ± 0.03
	Day 1	0.79 ± 0.16^c	0.47 ± 0.14^a
Serum creatinine (μmol/L)	Day 0	52 ± 4	57.6 ± 1.8
	Day 1	72 ± 5^d	63.7 ± 6.9
ClCr/100 g weight (mL/min)	Day 0	0.38 ± 0.03	0.34 ± 0.02
	Day 1	0.28 ± 0.03^c	0.32 ± 0.03
Urea (mmol/L)	Da.y 0	6.6 ± 0.3	7.1 ± 0.2
	Day 1	25.9 ± 4.0^d	32.8 ± 3.8^d
TRNa (%)	Day 0	99.67 ± 0.05	99.58 ± 0.04
	Day 1	99.84 ± 0.03	99.61 ± 0.11
FEK (%)	Day 0	8.4 ± 0.5	8.9 ± 0.5
	Day 1	19.3 ± 2.5^d	13.4 ± 0.9^c

PCr – serum creatinine; ClCr – creatinine clearance; TRNa – tubular reabsorption of sodium; FEK – fractional excretion of potassium.

p < 0.05 ^a; b – p < 0.01 ^b; p < 0.005 ^c; p < 0.001 ^d, vs. baseline, paired t-test.

Figure 1 Morphologic assessment of tubular damage in the Control (CTR) and EPO groups. The extent of tubular necrosis among S3 segments of the proximal tubules in the outer stripe, as well as medullary thick ascending limbs (mTALs) in the outer- (A), mid- (B), and inner (C) zones of the inner stripe of the outer medulla are expressed as the percentage of damaged tubules out of all tubules counted. Papillary damage is assessed semi-quantitatively, using a 0–3 score. *p = 0.03 vs. CTR, unpaired t-test.