Serum Leptin, Resistin, and Lipid Levels in Patients with End Stage Renal Failure with Regard to Dialysis Modality

Figures & data

Table 1 Demographic and laboratory findings of three groups

	HD patients	CAPD patients	Controls	p
Sex (Female/male)	17/13	18/12	17/13	NS
Age (years)	48.2 ± 15.5	43.3 ± 10.8	40.9 ± 10.0	NS
Weight (kilogram)	61.3 ± 14.8	66.4 ± 14.0	64.4 ± 11.3	NS
BMI (kg/m^2)	23.3 ± 4.7	25.4 ± 5.9	25.1 ± 3.9	NS
Glucose (mg/dL)	93.1 ± 23.3	98.9 ± 20.1	83.4 ± 7.4	NS
HsCRP (mg/L)	8.7 ± 8.9	8.6 ± 11.9	2.9 ± 1.1	p < 0.05^†^‡
Leptin (ng/mL)	11.5 ± 22.3	59.8 ± 61.5	7.9 ± 7.0	p < 0.05^‡
Adiponectin (ng/mL)	21.6 ± 10.1	37.7 ± 36.5	11.6 ± 5.1	p < 0.05^†^‡
Resistin (ng/mL)	41.9 ± 10.3	65.3 ± 28.5	17.9 ± 8.0	p < 0.05^†^‡
Interleukin-6 (pg/mL)	14.4 ± 14.9	15.9 ± 24.0	6.0 ± 5.4	p < 0.05^†^‡
TNF-α (pg/mL)	25.1 ± 7.3	30.3 ± 13.2	8.1 ± 3.1	p < 0.05^†^‡
Insulin (uIU/mL)	17.6 ± 11.6	27.9 ± 20.8	15.1 ± 14.0	p < 0.05^‡
HOMA-IR index	3.8 ± 2.8	5.6 ± 3.5	2.9 ± 2.4	p < 0.05^‡

Abbreviations: BMI = body mass index, TNF-α = tumor necrosis factor, HsCRP = high sensitive C reactive protein, IL-6 = interleukin 6.

*HD-CAPD significant, ^†HD-controls significant, ^‡CAPD-controls significant.

Table 2 Demographic and laboratory findings of dialysis patients

	Hemodialysis 30 patients	Peritoneal dialysis 30 patients	p
Duration of dialysis (months)	35.1 ± 32.4	38.7 ± 32.6	NS
Urinary Ccr (mL/min/)	2.6 ± 2.8	4.3 ± 3.1	p < 0.05
Glucose (mg/dL)	93.1 ± 23.3	98.9 ± 20.1	NS
Triglycerides (mg/dL)	152.0 ± 53.4	192.0 ± 74.9	p < 0.05
Total cholesterol (mg/dL)	149.2 ± 34.8	186.8 ± 33.7	p < 0.05
HDLc (mg/dL)	35.0 ± 8.7	47.7 ± 13.2	p < 0.05
LDLc (mg/dL)	81.0 ± 28.3	93.7 ± 37.8	NS

Abbreviations: Ccr = Creatinine clearance, HDLc = high-density lipoprotein cholesterol, LDLc = low-density lipoprotein cholesterol, BUN = blood urea nitrogen, NS = non-significant.

Table 3 Results of correlation analyses in HD patients

	HsCRP r	Leptin r	Adiponectin r	Resistin r	IL-6 r	TNF-α r
Age (years)	0.648	NS	NS	NS	0.436	NS
Duration of dialysis (months)	NS	NS	NS	NS	NS	NS
Weight (kilogram)	0.394	NS	−0.446	−0.390	NS	NS
BMI (kg/m^2)	NS	0.466	−0.408	NS	NS	NS
Total adipose tissue mass	NS	0.585	NS	NS	NS	NS
Total cholesterol (mg/dL)	NS	0.391	NS	NS	NS	NS
LDLc (mg/dL)	NS	0.372	NS	NS	NS	NS
HDLc (mg/dL)	NS	NS	0.491	NS	NS	NS
Triglycerides (mg/dL)	NS	0.381	NS	NS	NS	NS
HsCRP (mg/L)	NS	NS	−0.393	NS	NS	NS
IL-6 (pg/mL)	NS	NS	NS	NS	NS	NS
TNF-α (pg/mL)	NS	NS	NS	NS	NS	NS
Leptin (ng/mL)	NS	NS	NS	NS	NS	NS
Adiponectin (ng/mL)	−0.393	NS	NS	NS	NS	NS
Resistin (ng/mL)	NS	NS	NS	NS	NS	NS
Insulin (uIU/mL)	NS	NS	NS	NS	NS	NS
Insulin resistance	NS	NS	NS	NS	NS	NS
Urinary Ccr(mL/min)	NS	NS	NS	NS	NS	NS

Abbreviations: NS = non-significant, BMI = body mass index, HDLc = high-density lipoprotein cholesterol, LDLc = low-density lipoprotein cholesterol, TNF-α: tumor necrosis factor, HsCRP = high sensitive C reactive protein, IL-6 = interleukin 6, Ccr = creatinine clearance.

*p < 0.05.

Table 4 Results of correlation analyses in CAPD patients

	HsCRP r	Leptin r	Adiponectin r	Resistin r	IL6 r	TNFr
Age (years)	NS	NS	NS	NS	0.436	NS
Weight (kilogram)	NS	NS	NS	0.694	NS	NS
Duration of dialysis (months)	NS	NS	0.643	NS	NS	NS
BMI (kg/m^2)	NS	NS	NS	0.839	NS	NS
Total cholesterol (mg/dL)	NS	0.391	NS	NS	NS	NS
Total adipose tissue mass (kg)	0.622	0.585	NS	0.862	NS	NS
LDLc (mg/dL)	NS	0.372	0.606	NS	NS	NS
HDLc (mg/dL)	NS	NS	NS	NS	NS	NS
Triglycerides (mg/dL)	NS	0.381	−0.515	0.751	NS	NS
HsCRP (mg/L)	NS	NS	NS	NS	NS	0.588
IL-6 (pg/mL)	NS	NS	NS	NS	NS	NS
Leptin (ng/mL)	NS	NS	NS	NS	NS	NS
Adiponectin (ng/mL)	NS	−0.393	NS	NS	NS	NS
Resistin (ng/mL)	NS	NS	NS	NS	NS	NS
TNF-α (pg/mL)	0.588	NS	NS	NS	NS	NS
Insulin (uIU/mL)	NS	NS	NS	NS	NS	NS
HOMA-IR index	0.700	NS	NS	NS	NS	NS
Urinary Ccr(mL/min)	NS	NS	NS	NS	NS	NS

Abbreviations: NS = non-significant, BMI = body mass index, BUN = blood urea nitrogen, HDLc = high-density lipoprotein cholesterol, LDLc = low-density lipoprotein cholesterol, TNF-α = tumor necrosis factor, HsCRP = high sensitive C reactive protein, IL-6 = interleukin 6, Ccr = Creatinine clearance.

*p < 0.05.