Comparison of Higher Dose of Losartan Treatment with Losartan Plus Carvedilol and Losartan Plus Ramipril in Patients with Glomerulonephritis and Proteinuria

Figures & data

Table 1 Patient demographics and the distribution of primary renal diseases in study population

	Gender						Primary disease
	Group	F/M	Age	Weight	Height	Hb	Uric acid	IgA	MGN	MPGN	FSGS	Proteinuria	sBP	dBP
Los + Los	1	1/6	42 ± 11	71 ± 10	171 ± 5	14.3 ± 1.8	5.7 ± 2.1	1	2	2	2	1.8 ± 1.1	137 ± 7	92 ± 5
Los + Ram	2	1/6	43 ± 15	75 ± 10	173 ± 9	14.2 ± 1.4	6.6 ± 1.4	2	4	0	1	2.2 ± 1.4	137 ± 5	87 ± 5
Los + Car	3	3/4	41 ± 12	73 ± 10	167 ± 11	13.1 ± 2.4	6.0 ± 1.8	2	2	2	1	1.5 ± 1.0	142 ± 9	92 ± 7

Abbreviations: Los = losartan, Ram = ramipril, Car = carvedilol, F = female, M = male, Hb = hemoglobin, sBP = systolic blood pressure (mmHg), dBP = diastolic blood pressure (mmHg), IgA = immune globulin A nephropathy, MGN = membranous glomerulonephritis, MPGN = membranoproliferative glomerulonephritis, FSGS = focal segmental glomerulosclerosis.

Table 2 The trends in laboratory values and blood pressures measured at baseline and at one, six, and twelve months

	Losartan + losartan			Losartan + ramipril				Losartan + carvedilol
	Baseline	One month	Sixth month	Twelfthmonth	Baseline	First month	Sixth month	Twelfth month	Baseline	First month	Sixth month	Twelfth month
Proteinuria (g/day)	1.6 ± 1.1	1.5 ± 1.5	1.3 ± 1.3	0.5 ± 0.7	2.1 ± 1.2	1.6 ± 1.1	1.8 ± 1.3	0.7 ± 0.7	1.4 ± 1.2	1.0 ± 0.6	0.9 ± 0.7	0.9 ± 0.9
sBP (mmHg)	130 ± 13	120 ± 10	110 ± 14	110 ± 10	131 ± 4	122 ± 5	120 ± 6	117 ± 5	130 ± 8	115 ±11	114 ±11	116 ± 5
dBP (mmHg)	85 ± 5	77 ± 5	70 ± 10	72 ± 5	82 ± 4	80 ± 0	75 ± 5	75 ± 5	82 ± 4	75 ± 5	71 ± 9	76 ± 5
Albumin (g)	4.3 ± 0.4	4.4 ± 0.4	4.4 ± 0.3	4.4 ± 0.3	3.9 ± 0.7	4.0 ± 0.7	4.0 ± 0.8	4.2 ± 0.5	4.0 ± 0.6	4.2 ± 0.5	4.3 ± 0.5	4.5 ± 0.2
Creatinine (mg/dL)	1.1 ± 0.2	1.1 ± 0.3	1.2 ± 0.3	1.1 ± 0.3	1.1 ± 0.3	1.1 ± 0.4	1.2 ± 0.3	1.0 ± 0.4	1.1 ± 0.3	1.1 ± 0.4	1.2 ± 0.4	1.3 ± 0.4
Cr.Cle (mL/min )	96 ± 27	93 ± 21	86 ± 23	94 ± 28	101 ± 25	105 ± 27	96 ± 21	114 ± 41	101 ± 34	99 ± 34	92 ± 21	92 ± 40
Sodium (mEq/lt)	140 ± 2	142 ± 1	141 ± 2	139 ± 1	141 ± 1	140 ± 3	138 ± 3	138 ± 2	140 ± 6	142 ± 2	141 ± 3	143 ± 3
Potassium (mEq/lt)	4.4 ± 0.3	4.2 ± 0.3	4.3 ± 0.3	4.0 ± 0.3	4.4 ± 0.7	4.5 ± 0.7	4.3 ± 0.7	4.5 ± 0.7	4.3 ± 0.4	4.3 ± 0.4	4.7 ± 0.3	4.5 ± 0.6

Abbreviations: m = month, sBP = systolic blood pressure, dBP = diastolic blood pressure, Cr.Cle = creatinine clearance.

*p < 0.05 compared with baseline.

Figure 1. The course of proteinuria during the study period.

Figure 2. The course of blood pressures during the study period.