Low Dose Intradermal Vaccination Is Superior to High Dose Intramuscular Vaccination for Hepatitis B in Unresponsive Hemodialysis Patients

Figures & data

Table 1 Demographical and laboratory parameters of HD patients

	ID (median/mean)		IM (median/mean)		p
Initial HBs-Ab (IU/L)	2	2.54 ± 2.74	4.3	4.89 ± 3.33	>0.05
Age (years)	60	56.24 ± 15.66	55.5	49.93 ± 19.22	>0.05
Dialysis vintage (months)	28	32.12 ± 14.77	29.5	42.21 ± 40.18	>0.05
BUN (mg/dL)	89	87.18 ± 10.90	84.5	89.14 ± 24.51	>0.05
Creatinine (mg/dL)	10.7	10.42 ± 2.45	9.2	9.89 ± 2.55	>0.05
Calcium (mg/dL)	9.2	8.93 ± 0.73	8.5	8.51 ± 0.96	>0.05
Phosphorus (mg/dL)	5.3	4.72 ± 1.44	5.8	5.68 ± 2.18	>0.05
Albumin (g/dL)	3.9	3.98 ± 0.27	3.7	3.78 ± 0.38	>0.05
T. cholesterol (mg/dL)	184	187.47 ± 56.23	176	169.21 ± 48.14	>0.05
Triglyceride (mg/dL)	166	187.94 ± 78.78	180	193.79 ± 86.66	>0.05
Hemoglobin (mg/dL)	10.1	10.33 ± 1.13	9.9	10.19 ± 1.53	>0.05
CRP (mg/L)	3	7.53 ± 10.57	4	11.86 ± 20.25	>0.05
PTH (pg/mL)	200	289.77 ± 239.38	305	441.43 ± 457.20	>0.05
Fe (μg/dL)	59	60.24 ± 17.74	58.5	59.86 ± 19.56	>0.05
Saturation of transferrin (%)	29	32.71 ± 15.05	29	31.14 ± 10.74	>0.05
Ferritin (ng/mL)	392	527.24 ± 422.01	387	465.29 ± 265.33	>0.05
NPNA (g/kg/day)	1.2	1.18 ± 0.12	1.19	1.16 ± 0.19	>0.05
BMI ((kg/m^2)	23	23.65 ± 2.12	23	23.21 ± 3.58	>0.05
Kt/V (urea)	1.2	1.25 ± 0.10	1.2	1.26 ± 0.11	>0.05
Erythropoietin(IU/week)	4000	3411.77 ± 2647.14	4000	4214.29 ± 3285.83	>0.05
Vitamin D (μg /week)	0	0.65 ± 1.62	0	1.00 ± 1.84	>0.05

Table 2 Comparison of response rates and HBs-Ab titers of two groups six months after the last vaccination dose

	Intradermal	Intramuscular	p
HBs-Ab quantitative(IU/L)	209.59 ± 239.79	52.79 ± 117.94	0.003
HBs-Ab qualitative	16 (94.1%)	7 (50%)	0.011