Atherosclerotic Risk Factors Among Ankle-Brachial Index and Toe-Brachial Index in Peritoneal Dialysis Patients

Figures & data

Table 1 Characteristics of the peritoneal dialysis patients

n = 146	Mean	±SD
Gender (M/F)	41/105
Age	48	±11
SBP (mmHg)	142	±27
DBP (mmHg)	87	±16
PP (mmHg)	57	±15
MAP (mmHg)	109	±21
BMI (kg/m^2)	22.5	±3.5
ABI	1.08	±0.12
TBI	0.79	±0.14
D/P Cr	0.66	±0.11
MTAC Cr (mL/min)	9.4	±4.6
Calcium (mg/dL)	10.1	±0.96
Inorganic phosphate (mg/dL)	5.2	±1.3
Ca×P	51.84	±14.9
i-PTH (pg/mL)	311.6	±333.7
Glucose AC (mg/dL)	114	±48
Alb (g/dL)	3.9	±0.4
TC (mg/dL)	205	±49
TG (mg/dL)	234.5	±196.5
Duration (month)	50	±34
Smoking	11/146
Alcohol	7/146

Abbreviations: SBP = systolic blood pressure; DBP = diastolic blood pressure, PP = pulse pressure, MAP = mean arterial pressure, BMI = body mass index, ABI = ankle-brachial index, TBI = toe-brachial index, D/P Cr = dialysate/plasma creatinine ratio, MTAC Cr = mass transfer area coefficient for creatinine, Ca×P = calcium-phosphate products, i-PTH = intact parathyroid hormone, glucose AC = fasting serum glucose, Alb = serum albumin, TC = total cholesterol, TG = triglyceride, smoke and alcohol = number of subjects having history of smoking and alcohol drinking.

Figure 1. Relationship between ankle-brachial index (ABI) and toe-brachial index (TBI) in peritoneal dialysis patients.

Table 2 Correlation coefficients between ABI/TBI and other variables

	ABI		TBI
	coefficient	p	coefficient	p
Male gender	0.002	0.98	−0.048	0.57
SBP (mmHg)	0.33	<0.001	0.023	0.78
DBP (mmHg)	0.39	<0.001	0.144	0.08
PP (mmHg)	0.19	0.02	−0.123	0.14
MAP (mmHg)	0.38	<0.001	0.098	0.24
Age	0.02	0.79	−0.146	0.08
BMI (kg/m^2)	−0.06	0.51	−0.117	0.16
D/PCr	−0.1	0.25	−0.042	0.62
MTAC Cr (mL/min)	−0.1	0.26	−0.028	0.74
Calcium (mg/dL)	−0.18	0.03	−0.076	0.37
Inorganic phosphate (mg/dL)	−0.003	0.97	<0.001	0.99
Ca×P	−0.08	0.36	−0.021	0.8
i-PTH (pg/mL)	−0.12	0.16	−0.123	0.14
Glucose.AC (mg/dL)	−0.07	0.43	−0.212	0.01
Alb (g/dL)	0.03	0.75	−0.102	0.22
TC (mg/dL)	−0.03	0.77	−0.202	0.02
TG	−0.08	0.33	−0.170	0.04
Duration (month)	−0.2	0.02	0.039	0.64
Smoking	0.05	0.52	−0.052	0.54
Alcohol	0.11	0.21	0.024	0.78

Abbreviations: ABI = ankle-brachial index, TBI = toe-brachial index, SBP = systolic blood pressure, DBP = diastolic blood pressure, PP = pulse pressure, MAP = mean arterial pressure, BMI = body mass index, D/P Cr = dialysate/plasma creatinine ratio, MTAC Cr = mass transfer area coefficient for creatinine, Ca×P = calcium-phosphate products, i-PTH = intact parathyroid hormone, glucose AC = fasting serum glucose, Alb = serum albumin, TC = total cholesterol, TG = triglyceride

Table 3 Results of step-wise multiple regression analysis to assess the correlation of ABI or TBI with other variables

Independent variables	Beta	t value	Significance	Constant
ABI and related parameters				0.691
MAP (mmHg)	0.347	4.554	<0.001
TBI (month)	0.295	3.868	<0.001
TBI and related parameters				0.54
ABI	0.304	3.825	<0.001
TC (mg/dL)	−0.171	−2.152	0.033
Glucose AC (mg/dL)	−0.166	−2.093	0.038

Abbreviations: ABI = ankle-brachial index, MAP = mean arterial paressure, TBI = toe-brachial index, glucose = fasting serum glucose, TC = total cholesterol.

Figure 2. No significant difference of ankle-brachial index (ABI) and toe-brachial index (TBI) in patients with different peritoneal equilibration test (PET) category: 1 = low, 2 = low average, 3 = high average, 4 = high. *p > 0.05 vs. group 4. The number in parentheses indicates the number of patients in each group.