Impact of acute kidney injury on renal allograft survival

Figures & data

Figure 1. Source of infection.

Figure 2. Staging of patients with AKI as per AKIN and RIFLE criteria.

Table 1. Analysis of risk factors for AKI.

Risk factors	AKI	Non-AKI	Univariate analysis	Multivariate analysis HR(95%CI)
Recipient age	42.8 ± 2.7	41.9 ± 3.6	0.34	–
Donor age	48.7 ± 4.9	48.5 ± 6.7	0.67	–
Mean serum creatinine (mg/dl)	1.5 ± 0.4	1.4 ± 0.6	0.64	–
Mean eGFR (ml/min/1.73m^2)	64.1 ± 12.4	65.8 ± 14.8	0.49	–
Total ischemic time (minutes)	92.4 ± 6.3	88.3 ± 7.4	0.54	–
Live donor	87	100	0.67
Deceased donor	25	7	0.04	2.73 (3.52–5.78) p = .008
NODAT	21	9	0.03	3.62 (1.23–6.62) p = .043
Induction Immunosuppression	39	31	0.47	–

Table 2. Risk factors for the progression to CKD.

Risk factors in AKI group (n = 112)	Normal graft function n (%)	CKD n (%)	Univariate analysis (p value)	Multivariate analysis HR(95%CI)
Multiple AKI episodes	12 (23.1%)	40 (76.9%)	0.008	6.92 (3.92–5.63) p = .008)
Dialysis requiring AKI	1 (20%)	4 (80%)	0.032	–
Time line of AKI
Less than a year	07 (11.5%)	54 (88.5%)	0.007	7.32 (4.37–5.32) p = .007)
1–5 years	12 (44.5%)	15 (55.5%)	0.715	–
More than 5 years	12 (52.1%)	11 (47.9%)	0.388	–
Etiology of AKI
Infections	20 (28.6%)	43 (71.4%)	0.002	3.62 (2.8–5.75) p = .03
Rejection	4 (10%)	36 (90%)	0.004	9.92 (5.56–7.36) p = .001)
Acute CNI toxicity	4 (20%)	16 (80%)	0.336	–

Figure 3. Mean graft survival between AKI and non-AKI group.

Figure 4. Time for doubling of creatinine between AKI and non-AKI group.