Predictive value of neutrophil/lymphocyte ratio in renal prognosis of patients with granulomatosis with polyangiitis

Figures & data

Table 1. General characteristics and results of inflammatory markers of the patients in the GPA and the control groups.

	GPA group (n = 53)	Control group (n = 39)	p Values
Age, mean ± SD	48.5 ± 14.3	49.5 ± 13.7	.728
Gender, % males	58.5	51.3	.53
NLR, (N/L count)	4.61 (0.62–46)	1.77 (1.04–2.9)	<.001
ESR, mm/h	46.5 (3–131)	8 (1–34)	<.001
CRP, mg/l	28.0 (1.27–300)	3.2 (1.16–7.4)	<.001

Figure 1. ROC analysis for NLR (AUC was 0.906 for >2.9 of NLR with 75% sensitivity, 100% specificity).

Figure 2. Baseline NLR correlated with serum creatinine level at baseline (Spearman’s rho. = 0.487, p < .001). Moreover, there was also a significant inverse correlation between baseline NLR and GFR at 6-month follow-up (Spearman’s rho = −0.296, p = .005).

Table 2. Comparison of patients in the renal and non-renal subgroups of the GPA patients at baseline.

	Renal GPA (n = 29)	Non-renal GPA (n = 24)	p Values
Age	47.0 ± 15.6	50.2 ± 12.8	.434
NLR	8.79 (1.26–46)	2.48 (0.62–8.17)	<.001
ESR, mm/h	49 (3–108)	38.5 (7.28–131)	.919
CRP, mg/dl	38.8 (1.27–300)	13.35 (5.51–250)	.371
Serum creatinine, mg/dl	2.07 (0.79–12.9)	0.75 (0.45–1.02)	<.001
GFR ml/min	33 (2.7–110)	98.65 (60–122)	<.001
BVAS	13 (0–24)	2.5 (0–21)	.009

The variables showing normal distribution are presented as mean ± SD while the skew distrusted variables are as median (min–max.).

Table 3. Comparison of GPA patients who have active or persistent disease with those in remission at 6-month follow-up according to the BVAS system.

	Active or persistent disease (n = 16)	Remission (n = 13)	p Values
NLR	6.55 (1.26–46)	3.64 (0.62–14.01)	.004
Serum creatinine, mg/dl	1.71 (0.5–13.91)	0.89 (0.45–7.30)	.001
GFR ml/min	36 (2.7–120)	86 (6.9–137)	.009

The variables showing skew distribution are presented as median (min–max.).