Figures & data
Figure 1. Two-way hierarchical clustering heat map of DEGs. The horizontal axis represents the different samples, the vertical axis represents the genes and the white to black represents the genes expression changed; the deeper the color, the high the expression levels. DEGs: differentially expressed genes.
![Figure 1. Two-way hierarchical clustering heat map of DEGs. The horizontal axis represents the different samples, the vertical axis represents the genes and the white to black represents the genes expression changed; the deeper the color, the high the expression levels. DEGs: differentially expressed genes.](/cms/asset/25114d30-a13a-4896-bc00-77022dd6c04b/irnf_a_1421556_f0001_b.jpg)
Table 1. Results of enrichment analysis of DEGs.
Figure 2. The PPI network of DEGs. Round represents the upregulated DEG; quadrilateral represents down-regulated DEG and the line represents the interaction. DEG: differentially expressed gene.
![Figure 2. The PPI network of DEGs. Round represents the upregulated DEG; quadrilateral represents down-regulated DEG and the line represents the interaction. DEG: differentially expressed gene.](/cms/asset/fe3c487b-4378-4575-a661-c6e9762ac0c5/irnf_a_1421556_f0002_b.jpg)
Table 2. Genes with node degree greater than 20 in PPI network.
Figure 3. The GO correlation of highest score sub-modules. Gray nodes represent the significant GO terms and white nodes represent the non-significant GO terms. Node in a larger node size and a darker color represents a more significant GO term; arrows indicate relevancy of the two GO terms. GO: gene ontology.
![Figure 3. The GO correlation of highest score sub-modules. Gray nodes represent the significant GO terms and white nodes represent the non-significant GO terms. Node in a larger node size and a darker color represents a more significant GO term; arrows indicate relevancy of the two GO terms. GO: gene ontology.](/cms/asset/46a9397e-e577-4a3d-8ceb-6c9958842ff4/irnf_a_1421556_f0003_b.jpg)
Figure 4. GO enrichment of the highest score sub-modules. Round nodes represent the upregulated genes; quadrilateral nodes represent down-regulated genes and the lines represent the interactions between the two nodes. White nodes represent these genes that are not significantly enriched in the pathway; the different colors are marked as specific GO classifications, blue: gene expression; purple: cellular macromolecule bio synthetic process; red: macromolecule biosynthetic process; rose red: translation and orange: translational elongation. GO: gene ontology (refer online version for color figure).
![Figure 4. GO enrichment of the highest score sub-modules. Round nodes represent the upregulated genes; quadrilateral nodes represent down-regulated genes and the lines represent the interactions between the two nodes. White nodes represent these genes that are not significantly enriched in the pathway; the different colors are marked as specific GO classifications, blue: gene expression; purple: cellular macromolecule bio synthetic process; red: macromolecule biosynthetic process; rose red: translation and orange: translational elongation. GO: gene ontology (refer online version for color figure).](/cms/asset/446209e5-5006-4b99-a450-66ff1b0648bd/irnf_a_1421556_f0004_c.jpg)
Figure 5. MiRNA-TF-DEGs regulatory network. The triangle nodes represent the up-regulated TFs; the quadrilateral nodes represent the down-regulated TFs; the arrow is the regulation relation; the circle nodes represent the target genesand diamond is the miRNA. DEG: differentially expressed gene; TF: transcription factor.
![Figure 5. MiRNA-TF-DEGs regulatory network. The triangle nodes represent the up-regulated TFs; the quadrilateral nodes represent the down-regulated TFs; the arrow is the regulation relation; the circle nodes represent the target genesand diamond is the miRNA. DEG: differentially expressed gene; TF: transcription factor.](/cms/asset/f958a364-bef5-4f9d-ac73-33e451d545d0/irnf_a_1421556_f0005_b.jpg)