Predictive role of endothelin in left ventricular remodeling of chronic kidney disease

Figures & data

Table 1. Level of ET-1 in enrolled patient with CKD ($\overline{x}$ ± s).

Stage	n	M/F	Average age (y)	GFR (ml/min·1.73 m^2)	ET-1 (ρ/ng·L^−1)
I	19	11/8	43.26 ± 11.56	≥90	59.94 ± 14.88
II	25	11/14	46.48 ± 12.23	60–89	102.49 ± 18.01*
III	23	12/11	48.95 ± 14.91	30–59	154.51 ± 47.69*&
IV	27	16/11	47.56 ± 12.58	15–29	189.15 ± 43.16*&Δ
V	23	11/12	49.68 ± 12.63	<15	190.39 ± 42.51*&Δ

M: male; F: female; ET-1: Endothelin-1; GFR: glomerular filtration rate.

* p < .01 vs. Stage I.

& p < .01 vs. Stage II.

Δ p < .01 vs. Stage III.

Table 2. Comparison in echocardiographic indicators ($\overline{x}$ ± s).

	Stage 1	Stage 2	Stage 3	Stage 4	Stage 5
LVDd (d/mm)	42.12 ± 4.23	45.10 ± 5.52Δ	49.43 ± 5.39Δ	49.17 ± 5.13Δ	49.76 ± 4.52Δ
IVST (δ/mm)	11.23 ± 2.14	11.38 ± 2.12	12.91 ± 1.68Δ	11.75 ± 1.19	12.98 ± 2.42Δ
LVPWT (δ/mm)	9.61 ± 0.69	9.20 ± 1.88	11.20 ± 1.49*	11.08 ± 1.64*	11.65 ± 3.46*
LVMI (g/m^2)	95.24 ± 28.67	129.2 ± 41.64Δ	149.96 ± 40.88Δ*	150.34 ± 41.78Δ*	149.91 ± 36.87Δ*
EF (%)	0.65 ± 0.06	0.59 ± 0.06Δ	0.65 ± 0.08*	0.60 ± 0.14Δ	0.59 ± 0.11Δ
E/A	0.94 ± 031	0.98 ± 0.42	0.92 ± 0.12*	0.65 ± 0.35Δ*	0.59 ± 0.25Δ*

Δ p < .01 vs. Stage 1.

* p < .01 vs. Stage 2.

Table 3. Correlation analysis of ET-1 and left ventricular changes^a.

x	y	r	p
ET-1	LVDd	0.331	.029
ET-1	IVST	0.429	.001
ET-1	LVPWT	0.254	.110
ET-1	LVMI	0.494	.000
ET-1	EF	0.36	.824
ET-1	E/A	−0.013	.935

^a Peng et al. [10].

Table 4. Multivariate regression analysis.

Regression equation	R^2	F	p
LVMI =49.31 + 1.003 × SBP +0.327 × ET-1	0.408	12.819	.000

Peng T, Hu Z, Wu L, et al. Correlation between endothelial dysfunction and left ventricular remodeling in patients with chronic kidney disease. Kidney Blood Press Res. 2014;39:420–426.

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