The influence of environmental factors on clinical pathological changes of patients with immunoglobulin A nephropathy from different areas of China

Figures & data

Figure. 1. The ratio of mucosal infections for IgAN patients in two groups. No mucosal infection in the Xi’an group was lower than that in the Guangzhou group. Upper respiratory infection and biliary tract infection in the Xi’an group was higher than that in the Guangzhou group. *p < .05 versus control.

Figure. 2. The clinical presentations of patients with IgAN in two groups. Abnormal urinalysis in the Xi’an group was lower than that in the Guangzhou group. Debilitation and lumbago in the Xi’an group was higher than that in the Guangzhou group. *p < .05 versus control.

Table 1. The comparison of clinical characteristics between the two groups.

Index	Guangzhou Group (n = 193)	Xi’an Group (n = 199)	p value
Serum uric acid (μmol/L)	383.26 ± 52.98	323.61 ± 59.69*	<.001
Triglyceride (mmol/L)	1.598 ± 1.19	1.80 ± 1.20*	.020
Serum alexin C3 (g/L)	1.02 ± 0.20	0.98 ± 0.19*	.008
Serum creatinine (μmmol/L)	103.95 ± 22.85	93.98 ± 16.03*	.003
Glomerular filtration rate (ml/min)	81.98 ± 12.43	102.96 ± 22.94*	<.001
Serum cholesterol (mmol/L)	5.37 ± 1.94	5.00 ± 1.80*	.008
Urine erythrocyte (n/μl)	73.17 ± 13.77	258.56 ± 54.94*	.002
Serum IgA level (g/L)	3.09 ± 0.98	2.89 ± 0.68	.107
Blood urea nitrogen (mmol/L)	5.95 ± 1.69	6.16 ± 1.88	.566
24-hour urinary protein quantity (g/24h)	1.73 ± 0.59	1.64 ± 0.53	.746

* p < .05, compared with Guangzhou group.

Figure. 3. The ratio of immune fluorescence components in two groups. The percentage of immune complex depositions in the mesangial area and capillary wall is shown. The number of the patients with the immune complex deposition was also shown.

Figure. 4. The renal lesions distributed in 392 patients in two groups by Lee Grade. All biopsies from 392 patients were graded by Lee’s classification. Distribution into the five different histological grades at the time of renal biopsy is shown. The symbol.