Association between Helicobacter pylori infection and kidney damage in patients with peptic ulcer

Figures & data

Table 1. H. pylori infection rate in the two groups.

Variable	Healthy controls (n = 390)	Patients with peptic ulcer (n = 194)	t/χ^2	p
Gender (M/F)	292/98	123/71	–	–
Age (years)	45.09 ± 9.19	46.07 ± 9.62	t=–1.191	.234
Fasting blood-glucose (mmol/L)	5.15 ± 0.48	5.16 ± 0.46	t=–0.252	.801
Systolic BP (mmHg)	119.08 ± 6.42	119.48 ± 5.84	t=–0.749	.455
Diastolic BP (mmHg)	69.98 ± 5.03	69.69 ± 5.53	t = 0.615	.539
BMI (kg/m²)	25.1 ± 3.2	25.7 ± 3.0	t=–1.204	.229
ALT (U/mL)	13.88 ± 5.78	14.43 ± 5.97	t=–1.077	.582
AST (U/mL)	15.81 ± 5.00	15.47 ± 5.71	t = 0.703	.483
H. pylori infection rate (M/F)	41.28% (41.78%/39.8%)	88.14% (89.43%/39.80%)	χ^2=115.98	<.001

BP: blood pressure; BMI: body mass index; ALT: alanine transaminase; AST: aspartate transaminase.

Figure 1. H. pylori-negative and H. pylori-positive subjects in two groups. Both ¹⁴C-urea breath test and rapid urease tests were utilized for identifying H. pylori infection in healthy controls and patients with peptic ulcer (IR: infection rate, **p<.01 vs. healthy control).

Table 2. The H. pylori infection and urine ACR in healthy controls.

Groups	ACR normal	ACR abnormal	Abnormal rates
H.pylorinegative	209 (13.11 ± 5.32)	20 (49.74 ± 26.07)	8.73% (20/229)
H. pyloripositive	150 (13.48 ± 6.94)	11 (55.57 ± 21.91)	6.83% (11/161)
χ^2			0.467
p			.571

Table 3. The urinary ACR and H. pylori infection in patients with peptic ulcer.

Groups	Urine ACR normal	Urine ACR abnormal	Abnormal rates
H. pylorinegative	23	0	0% (0/23)
H. pylori positive	144	27	15.79% (27/171)
p			.040

Table 4. The H. pylori infection severity level and urinary ACR abnormal severity.

Infection severity	Number	ACR (mg/g)
H. pylori (+)	9	106.90 ± 111.54
H. pylori (++)	15	93.03 ± 169.70
H.pylori (+++)	3	57.40 ± 21.86
rs		–0.198
p		.323

Figure 2. The urinary ACR between pretreatment and post-treatment in H. pylori infection patients with peptic ulcer. ACR of five subjects was significantly decreased after 3 month routine H. pylori eradication therapy by urine ACR test.