Serum insulin-like growth factor-binding protein 2 levels as an indicator for disease severity in enterohemorrhagic Escherichia coli induced hemolytic uremic syndrome

Yuko Tasakia Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan

Natsumi Inouea Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan

Masaki Shimizub Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanCorrespondence[email protected]

https://orcid.org/0000-0003-1077-7772

Naotoshi Sugimotoc Department of Physiology, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan

Sayaka Ishikawad Department of Pediatrics, Fukui Saiseikai Hospital, Fukui, Japan

Mao Mizutaa Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan

Tadafumi Yokoyamaa Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan

Mondo Kurodaa Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan

Kazuhide Ohtae Department of Pediatrics, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan

Akihiro Yachief Division of Medical Safety, Kanazawa University Hospital, Kanazawa, Japan

Taizo Wadaa Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan

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Table 1. Clinical characteristics of patients with EHEC-induced HUS.

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Figure 1. IGFBP2 production is induced by Stx-2 and LPS in RGECs. Data presented as mean (±standard error of the mean) of four experiments. Stx-2 dose-dependently induced the production of IGFBP2 in RGECs. LPS also induced the production of IGFBP2 in RGECs. Of note, there is no synergistic effect of STx2 on LPS-induced IGFBP2 production. *p<.05, **p<.01, and ***p<.001. LPS: lipopolysaccharide; RGEC: renal glomerular endothelial cell; Stx-2: Shiga toxin 2.

Figure 2. Serum IGFBP2 levels in patients with HUS. Bars represent median values. *p<.05 and ****p<.0001. HCs: healthy controls; IGFBP2: insulin-like growth factor-binding protein 2.

Figure 3. Changes in serum IGFBP2 levels in patients with HUS. Changes in serum IGFBP2 levels from the hemorrhagic colitis phase to the time of HUS diagnosis are shown. Serum IGFBP2 levels in encephalopathy group showed a significant and sharp increase with the progression of HUS, whereas no increase in serum IGFBP2 levels was observed in mild group. *p<.05.

Figure 4. Correlations between serum IGFBP levels and serum tau and cytokine levels in patients with EHEC-HUS. (A) Tau (n = 21), (B) neopterin (n = 22), (C) interleukin 6 (IL-6; n = 22), (D) soluble tumor necrosis factor receptor (sTNFR) I (n = 22), and (E) sTNFR-II (n = 22).

Serum insulin-like growth factor-binding protein 2 levels as an indicator for disease severity in enterohemorrhagic Escherichia coli induced hemolytic uremic syndrome

Table 1. Clinical characteristics of patients with EHEC-induced HUS.

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Serum insulin-like growth factor-binding protein 2 levels as an indicator for disease severity in enterohemorrhagic Escherichia coli induced hemolytic uremic syndrome

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Table 1. Clinical characteristics of patients with EHEC-induced HUS.

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