Relation between insulin growth factor 1 and survival after SARS-CoV-2(COVID 19) infection in elderly kidney transplant recipients

Figures & data

Table 1. Laboratory data of elderly renal transplant recipients with and without cardiac dysfunction before and after Covid 19 infection.

	Group one (Patients without cardiac dysfunction)	Group two (Patients with cardiac dysfunction)	p Value
Human growth hormone before(SARS-CoV-2)
Mean ± SD	1.27 ± 0.18	4.35 ± 1.39	<0.001
Median(IQR)	1.3(1.1:1)	4.9(3.8:5)
Human growth hormone after (SARS-CoV-2)
Mean ± SD	1.21 ± 0.16	3.3 ± 0.99	<0.001
Median(IQR)	1.2(1.1:1)	2.8(2.5:4)
Insulin Growth Factor 1 (IGF1) before (SARS-CoV-2)
Mean ± SD	190.57 ± 19.26	67.44 ± 21.24	<0.001
Median(IQR)	196(179:205)	60(52:85)
IGF1 after (SARS-CoV-2)
Mean ± SD	209.71 ± 48.4	129.78 ± 39.43	0.002
Median(IQR)	195(190:225)	123(98:150)
Spearman's rho	Q sofa score
	r	p Value
Group without cardiac dysfunction
IGF1 before Covid19	0.408	0.363
IGF1 after Covid19	0.618	0.139
Group with cardiac dysfunction
IGF1 before Covid19	−0.149	0.702
IGF1 after Covid19	0.894	0.001

Table 2. Relation between recovery and HGH and IGF 1 in elderly transplanted recipients with and without cardiac dysfunction.

	Recovery
	No	Yes	p Value
Group without cardiac dysfunction
IGF1 after (SARS-CoV-2)
Mean ± SD	310±.	163 ± 21.54	0.02
Median(IQR)	310(310:310)	162.5(160:170)
Group with cardiac dysfunction
IGF1 after (SARS-CoV-2)
Mean ± SD	166.25 ± 22.49	100.6 ± 18.31	0.016
Median(IQR)	164(147.5:185)	98(88:115)
Group without cardiac dysfunction
Human growth hormone after Covid19
Mean ± SD	1±.	1.25 ± 0.14	0.286
Median(IQR)	1(1:1)	1.2(1.2:1.3)
Group with cardiac dysfunction
Human growth hormone after Covid19
Mean ± SD	2.88 ± 0.99	3.64 ± 0.94	0.19
Median(IQR)	2.5(2.2:3.6)	3.9(2.8:4.4)
	Ventilation		p Value
	No	Yes
Group without cardiac dysfunction
IGF1 after (SARS-CoV-2)
Mean ± SD	186.6 ± 16.52	267.5 ± 60.1	0.095
Median(IQR)	190(190:195)	267.5(225:310)
Group with cardiac dysfunction
IGF1 after (SARS-CoV-2)
Mean ± SD	97 ± 18.99	156 ± 30.07	0.032
Median(IQR)	93(83.5:111)	150(145:178)