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Renal Failure Volume 44, 2022 - Issue 1
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Clinical Study

Proton pump inhibitor usage is associated with higher all-cause mortality and CV events in peritoneal dialysis patients

Yingsi Zenga Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Lingling Liub Department of General Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaView further author information
,
Liya Zhua Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Xiaojiang Zhanc Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaView further author information
,
Fenfen Pengd Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaView further author information
,
Xiaoran Fenge Department of Nephrology, Jiujiang NO.1 People’s Hospital, Jiangxi, ChinaView further author information
,
Qian Zhouf Department of Medical Statistics, Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-sen Univeristy, Guangzhou, ChinaView further author information
,
Yujing Zhanga Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Zebin Wanga Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Jianbo Lianga Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Jiao Lia Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China;g Department of Cardiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaCorrespondence[email protected]
View further author information
&
Yueqiang Wena Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 398-405 | Received 05 Jul 2021, Accepted 09 Feb 2022, Published online: 02 Mar 2022

Figures & data

Figure 1. Flow chart including patient enrollment and outcomes.

Figure 1. Flow chart including patient enrollment and outcomes.

Table 1. Patient demographic and clinical characteristics.

Table 2. Significant risk factors for all-cause mortality and CV events.

Figure 2. Cumulative incidence curves for mortality and CV events by category of the use of PPI. (A) Cumulative incidence curves for all-cause mortality. (B) Cumulative incidence curves for the incidence of CV events. The curves were constructed using the Kaplan–Meier method and compared using the Mantel–Cox log-rank test.

Figure 2. Cumulative incidence curves for mortality and CV events by category of the use of PPI. (A) Cumulative incidence curves for all-cause mortality. (B) Cumulative incidence curves for the incidence of CV events. The curves were constructed using the Kaplan–Meier method and compared using the Mantel–Cox log-rank test.

Figure 3. Cumulative incidence curves for mortality and CV events by category of the usage of PPI after IPTW. (A) Cumulative incidence curves for all-cause survival. (B) Cumulative incidence curves for the incidence of CV events. The curves were constructed using the Kaplan–Meier method and compared using the Mantel–Cox log-rank test.

Figure 3. Cumulative incidence curves for mortality and CV events by category of the usage of PPI after IPTW. (A) Cumulative incidence curves for all-cause survival. (B) Cumulative incidence curves for the incidence of CV events. The curves were constructed using the Kaplan–Meier method and compared using the Mantel–Cox log-rank test.

Table 3. Relationship between PPI and the adverse prognosis.

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