1,995
Views
0
CrossRef citations to date
0
Altmetric
Clinical Study

Prediction models for risk of diabetic kidney disease in Chinese patients with type 2 diabetes mellitus

, , & ORCID Icon
Pages 1455-1462 | Received 25 May 2022, Accepted 09 Aug 2022, Published online: 29 Aug 2022

Figures & data

Table 1. Baseline characteristics stratified by DKD occurrence in enrolled T2DM patients.

Figure 1. Receiver operating characteristic (ROC) curve for DKD predictive models based on multivariate logistic regression analysis. (A) ROC curve for model 1 showed that its AUC for predicting DKD was 0.8943. Its optimal cutoff value was 0.26, with a specificity and sensitivity of 0.764 and 0.852, respectively. (B) ROC curve for model 2 showed that its AUC for predicting DKD was 0.8946. Its optimal cutoff value was 0.22, with a specificity and sensitivity of 0.797 and 0.818, respectively.

Figure 1. Receiver operating characteristic (ROC) curve for DKD predictive models based on multivariate logistic regression analysis. (A) ROC curve for model 1 showed that its AUC for predicting DKD was 0.8943. Its optimal cutoff value was 0.26, with a specificity and sensitivity of 0.764 and 0.852, respectively. (B) ROC curve for model 2 showed that its AUC for predicting DKD was 0.8946. Its optimal cutoff value was 0.22, with a specificity and sensitivity of 0.797 and 0.818, respectively.

Table 2. Prediction models for DKD by the forward selection method (Model 1) and the backward elimination method (Model 2).

Figure 2. Nomograms to predict the 3-year risk of diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes (T2DM). Note: The renal nomogram was developed in the cohort, with variables, age, UACR, eGFR, and neutrophils percentages. Steps to estimate the DKD risk: first, obtain the point for each variable by drawing a vertical line from the value to the scoring ruler; second, summate points for all variables to calculate a total point; finally, evaluate the risk of DKD onset by drawing a vertical line from the total points to the predicted risk ruler. Abbreviations: UACR, urinary albumin to creatinine ratio; eGFR, estimated glomerular filtration rate.

Figure 2. Nomograms to predict the 3-year risk of diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes (T2DM). Note: The renal nomogram was developed in the cohort, with variables, age, UACR, eGFR, and neutrophils percentages. Steps to estimate the DKD risk: first, obtain the point for each variable by drawing a vertical line from the value to the scoring ruler; second, summate points for all variables to calculate a total point; finally, evaluate the risk of DKD onset by drawing a vertical line from the total points to the predicted risk ruler. Abbreviations: UACR, urinary albumin to creatinine ratio; eGFR, estimated glomerular filtration rate.
Supplemental material

Supplemental Material

Download PDF (293.2 KB)

Supplemental Material

Download PDF (20.9 KB)

Supplemental Material

Download PDF (96.4 KB)

Supplemental Material

Download PDF (146.5 KB)

Supplemental Material

Download PDF (61.1 KB)