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Renal Failure Volume 45, 2023 - Issue 1
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Clinical Study

Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients

Ping Zhanga Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;b Kidney Disease Center, Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China;c Kidney Disease Center, National Key Clinical Department of Kidney Diseases, Hangzhou, China;d Institute of Nephrology, Zhejiang University, Hangzhou, China;e Kidney Disease Center, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaView further author information
,
Shilong Xianga Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;b Kidney Disease Center, Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China;c Kidney Disease Center, National Key Clinical Department of Kidney Diseases, Hangzhou, China;d Institute of Nephrology, Zhejiang University, Hangzhou, China;e Kidney Disease Center, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaView further author information
,
Bicheng Liuf Department of Nephrology, ZhongDa Hospital, Southeast University, Chongqing, ChinaView further author information
,
Xiaohui Wangg Department of Nephrology, Fifth Hospital in Wuhan, Wuhan, ChinaView further author information
,
Xiaoping Yangh Department of Nephrology, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, ChinaView further author information
,
Chaoyang Yei Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
,
Zunsong Wangj Department of Nephrology, Shandong Province QianFoshan Hospital, Jinan, ChinaView further author information
,
Yanlin Lik Department of Nephrology, Zhongshan Traditional Chinese Medicine Hospital, Guangzhou, ChinaView further author information
,
Li Zhoul Department of Nephrology, West China Hospital of Sichuan University, Chengdu, ChinaView further author information
,
Caili Wangm Department of Nephrology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, ChinaView further author information
,
Hongbo Lin Department of Nephrology, Wuhan No.1 Hospital, Wuhan, ChinaView further author information
,
Jian Huango Department of Nephrology, Jinhua Municipal Central Hospital, Jinhua, ChinaView further author information
,
Ai Pengp Department of Nephrology, Shanghai Tenth People’s Hospital, Shanghai, ChinaView further author information
,
Xiaoping Wangq Department of Nephrology, The Central Hospital of Jinan, Jinan, ChinaView further author information
,
Deguang Wangr Department of Nephrology, The Second Hospital of Anhui Medical University, Hefei, ChinaView further author information
,
Jie Xiaos Department of Nephrology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Wenli Chent Department of Nephrology, The Central Hospital of Wuhan, Wuhan, ChinaView further author information
,
Hong Chengu Department of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaView further author information
,
Nan Maov Department of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, ChinaView further author information
,
Jianqin Wangw Department of Nephrology, Lanzhou University Second Hospital, Lanzhou, ChinaView further author information
,
Lin Yangx Department of Nephrology, Yichang Central People’s Hospital, Yichang, ChinaView further author information
&
Jianghua Chena Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;b Kidney Disease Center, Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China;c Kidney Disease Center, National Key Clinical Department of Kidney Diseases, Hangzhou, China;d Institute of Nephrology, Zhejiang University, Hangzhou, China;e Kidney Disease Center, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaCorrespondence[email protected]
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Article: 2175590 | Received 19 Oct 2022, Accepted 27 Jan 2023, Published online: 01 Mar 2023

Figures & data

Table 1. Characteristic of patients at baseline (FAS).

Table 2. The summary of primary endpoint.

Table 3. The summary change of mean larger Xie-kawashima itch scale between latter seven-day pre-observation and latter seven-day treatment period.

Figure 1. Flow diagram of the progress through the randomized trial. 

Figure 1. Flow diagram of the progress through the randomized trial. 

Figure 2. The trend of mean larger Xie-kawashima itch scale during the study period. 

Figure 2. The trend of mean larger Xie-kawashima itch scale during the study period. 

Figure 3. The trend of mean Xie-kawashima itch scale in evening during the study period. 

Figure 3. The trend of mean Xie-kawashima itch scale in evening during the study period. 

Table 4. The summary change of mean Xie-kawashima itch scale in evening between latter seven-day pre-observation and latter seven-day treatment period.

Table 5. The summary of improvement of VAS value and effect.

Table 6. The summary of adverse events.

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