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Renal Failure Volume 45, 2023 - Issue 1
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Letter to the Editor

A rare case of membranous nephropathy associated with chronic inflammatory demyelinating polyradiculoneuropathy

Qiong Zhanga Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;b Institute of Nephrology, Peking University, Beijing, China;c Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;d Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China;e Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China;f Department of Nephrology, The Fifth Hospital of Shanxi Medical University, Jinzhong, ChinaView further author information
,
Ying Tana Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;b Institute of Nephrology, Peking University, Beijing, China;c Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;d Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China;e Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
,
Lingchao Mengg Department of Neurology, Peking University First Hospital, Beijing, ChinaView further author information
,
Rong Xua Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;b Institute of Nephrology, Peking University, Beijing, China;c Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;d Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China;e Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
,
Fude Zhoua Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;b Institute of Nephrology, Peking University, Beijing, China;c Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;d Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China;e Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, ChinaView further author information
&
Minghui Zhaoa Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;b Institute of Nephrology, Peking University, Beijing, China;c Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;d Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China;e Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China;h Peking-Tsinghua Center for Life Sciences, Beijing, ChinaCorrespondence[email protected]
View further author information
Article: 2209659 | Received 15 Feb 2023, Accepted 27 Apr 2023, Published online: 05 Jun 2023

Figures & data

Figure 1. Histologic findings on renal biopsy. (A) Light microscopy showed the glomerular basement membrane thickened diffusely, with the formation of segmental spikes (periodic methenamine silver and Masson trichrome staining, ×400); (B) immunohistochemical staining of phospholipase A2 receptor (×200); (C) electron microscopy showed uniform diffuse thickening of the glomerular basement membrane (830 nm) with the formation of segmental spikes; (D–I) immunofluorescent staining for IgG, IgG1, IgG2, C3, kappa, and lambda granular staining along glomerular basement membrane.

Figure 1. Histologic findings on renal biopsy. (A) Light microscopy showed the glomerular basement membrane thickened diffusely, with the formation of segmental spikes (periodic methenamine silver and Masson trichrome staining, ×400); (B) immunohistochemical staining of phospholipase A2 receptor (×200); (C) electron microscopy showed uniform diffuse thickening of the glomerular basement membrane (830 nm) with the formation of segmental spikes; (D–I) immunofluorescent staining for IgG, IgG1, IgG2, C3, kappa, and lambda granular staining along glomerular basement membrane.

Figure 2. The clinical course of the current case. RTX: rituximab; IVIg: intravenous immunoglobulin; Pred: prednisone; MRS: modified Rankin Scale.

Figure 2. The clinical course of the current case. RTX: rituximab; IVIg: intravenous immunoglobulin; Pred: prednisone; MRS: modified Rankin Scale.
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